Synthesis of Co+2, Ni+2, Cu+2, and Zn+2 complexes of Schiff base 5-methyl-3-((3,5-dichlorosalicylidene) amino)-pyrazole, spectral, and biological studies

Devi, Priyanka; Singh, Kiran; Dabas, Pooja

doi:10.1080/00958972.2022.2035726

Cited by 4 publications

(3 citation statements)

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“…The magnetic moment measurement of 3.70 B.M. confirms the octahedral geometry of the Ni(II) complex [2,16].…”

Section: Characterizationsupporting

confidence: 61%

“…These include antioxidant, anti-bacterial, anti-fungal, anti-tumour, anti-malarial, anti-fever and anti-inflammatory properties. Their use as ligands in complexes is related to their versatile applications such as enhancing biological or catalytic activity, providing higher thermal stability, obtaining porous coordination compounds (1D, 2D or 3D) or even as corrosion inhibitors [1][2][3][4][5].…”

Section: Introductionmentioning

confidence: 99%

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A Novel Ni(II) Complex: Synthesis, Spectral and Biological Activity Determination Studies

2023

Proceeding Book of 3rd International Conference on Scientific and Academic Research ICSAR 2023

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A new Ni(II) metal complex of the ligand ((E) methyl 6-benzyl-2-(4-(benzoxy)benzylideneamino)-4, 5,6,7-tetrahydrothieno[2,3-c]pyridine-3-carboxylate), derived from (methyl 2-amino-6-benzyl-4,5,6,7-tetrahydrothieno[2,3-c]pyridine-3-carboxylate) and 4benzoxybenzaldehyde, has been obtained. Standard spectroscopic techniques were used to elucidate the structural features of the ligand and its nickel (II) complex (elemental analysis, Fourier transform infrared (FT-IR) spectra, 1 H-NMR (proton nuclear magnetic resonance), elemental analysis, molar conductance, UV-Vis ( ultraviolet-visible) spectra, magnetic susceptibility, LC-Mass spectrometry, and TGA (thermogravimetric analysis). The analytical data showed that the Ni(II) complex is located in the ligand: metal ratio (1:1). Spectral studies revealed that the ligand bonds bidentate to the Ni metal ion via the nitrogen atom of the CH=N (azomethine) group and the oxygen atom of the C=O (carbonyl) group. A distorted octahedral structure can be suggested for the Ni(II) complex from electronic spectrum data and magnetic susceptibility values. The in vitro antioxidant and enzyme inhibition activities of Ni(II) complex were investigated. Acetylcholineesterase enzyme inhibition potential of the synthesized Ni(II) complex was found to be close to the standard tacrine compound. The Ni(II) complex was evaluated for its in vitro antioxidant activity according to the DPPH (1,1-Diphenyl-2-picrylhydrazyl) free radical scavenging activity and CUPRAC (cupric ions reducing capacity) in vitro bioanalytical methods. The synthesized Ni(II) complex showed effective antioxidant activity according to the both CUPRAC and DPPH method.

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“…The magnetic moment measurement of 3.70 B.M. confirms the octahedral geometry of the Ni(II) complex [2,16].…”

Section: Characterizationsupporting

confidence: 61%

Section: Introductionmentioning

confidence: 99%

A Novel Ni(II) Complex: Synthesis, Spectral and Biological Activity Determination Studies

2023

Proceeding Book of 3rd International Conference on Scientific and Academic Research ICSAR 2023

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“…The Schiff base is used as a biological model to recognize the structure, shape and biological reaction processes of biomolecules. It is also used as a catalyst in many reactions [1][2][3].…”

Section: Introductionmentioning

confidence: 99%

Synthesis, Characterization, Enzyme Inhibition and Antioxidant Activity of NickelII Complex of a Schiff Base

2023

Proceeding Book of 3rd International Conference on Scientific and Academic Research ICSAR 2023

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A novel active Ni II complex of the Schiff base ligand ((E)-methyl-6-benzyl-2-(2-hydroxy-3methoxybenzylideneamino)-4, 5,6,7-tetrahydrothieno[2,3-c]pyridine-3-carboxylate) has been synthesized. FT-IR, UV-Vis, NMR, microanalysis, mass spectroscopy and physical studies (TGA, molar conductivity, melting point) were used to characterize the newly prepared Ni II complex. Various characterization data suggested that the Schiff base ligand, coordinated by the nitrogen atom of the azomethine, the oxygen atom of the carbonyl and the oxygen atom of the hydroxyl group. Then, deprotonation with metal ions in a molar ratio of 1:1, has the general formula [LNiCl(H2O)2]•H2O. The low molar conductivity values confirmed the non-electrolytic structure of the Ni II complex. Thermal decomposition of the Ni II complex was shown to yield a metal oxide and OCH3 as residue. The octahedral geometry of the Ni II complex was confirmed by microanalysis, mass spectroscopy, UV-Vis, magnetic susceptibility and FT-IR spectroscopy. The Ni II complex was evaluated for its in vitro antioxidant activity by DPPH (1,1-diphenyl-2-picrylhydrazyl) radical scavenging activity and CUPRAC (cupric ion reduction capacity) in vitro bioanalytical methods. According to the CUPRAC method, the synthesized Ni II complex was found to have potent antioxidant activity. In contrast to standard antioxidants, the Ni II complex did not scavenge DPPH radical solution.

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Synthesis and antitumor activities of five Cu(II) complexes of bis(5-halosalicylidene)-1,3-propanediamine derivatives

Zhao

Chen

et al. 2022

Metallomics

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The development of metal complexes of Schiff base has attracted much attention due to their DNA binding properties and extensive biological activities. We reported here five copper(II) complexes [Cu(L1)] (1), [Cu(L2)] (2), [Cu(L3)] (3), [Cu2(L4)(OAc)] (4) and [Cu2(L5)(HCOO)] (5) bearing the bis-Schiff base ligands of bis(5-chlorosalicylidene)-1,3-propanediamine (H2L1), bis(5-chlorosalicylidene)-2-methyl-1,3-propanediamine (H2L2), bis(5-bromosalicylidene)-2-methyl-1,3-propanediamine (H2L3), bis(5-chlorosalicylidene)-2-hydroxyl-1,3-propanediamine (H3L4) and bis(5-bromosalicylidene)-2-hydroxyl-1,3-propanediamine (H3L5), respectively. The single crystal X-ray diffraction analysis results revealed that complexes 1-3 present mononuclear structures and complexes 4 and 5 show dinuclear structures. It was also shown that all of these complexes are stable under physiological conditions. The in vitro antitumor activities of the five complexes were evaluated. Anticancer selectivity was also found for complex 2 on different cell lines with the lowest IC50 value on Hela cells. The further mechanistic studies showed that the three mononuclear Cu(II) complexes can induce apoptosis through mitochondrial pathway by decreasing mitochondrial membrane potential and increasing the reactive oxygen species (ROS) and Ca2+ levels. They can activate caspase-3 and caspase-9, and can also regulate the expression of pro-apoptotic protein and anti-apoptotic protein in cells. All of these results showed that complex 2 is a potential anticancer drug.

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Synthesis of Co⁺², Ni⁺², Cu⁺², and Zn⁺² complexes of Schiff base 5-methyl-3-((3,5-dichlorosalicylidene) amino)-pyrazole, spectral, and biological studies

Cited by 4 publications

References 55 publications

A Novel Ni(II) Complex: Synthesis, Spectral and Biological Activity Determination Studies

A Novel Ni(II) Complex: Synthesis, Spectral and Biological Activity Determination Studies

Synthesis, Characterization, Enzyme Inhibition and Antioxidant Activity of NickelII Complex of a Schiff Base

Synthesis and antitumor activities of five Cu(II) complexes of bis(5-halosalicylidene)-1,3-propanediamine derivatives

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