Synthesis of co-crystals of anti-cancer nandrolone as a potential leads towards treatment of cancer

Iqbal, Urooj; Choudhary, M. Iqbal; Yousuf, Sammer

doi:10.1016/j.molstruc.2020.128981

Cited by 9 publications

(5 citation statements)

References 28 publications

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“…were present in its aqueous extract. The biologically active geraniol, grandisol (the boll weevil pheromone), neric acid (a pheromone), neophytadiene, n -hexadecanoic acid, phytol, octadecanoic acid (anti-inflammatory, antioxidant, anticancer), hexacosene, and nandrolone (anticancer) were observed in the investigated ethanolic extract of C. citratus while its aqueous extract contained cyclopentasiloxane (antioxidant), cis-linalool oxide (antifungal and antitermitic), trans-linalool oxide (pyranoid), pentasiloxane, hexadecanoic acid, , and hexasiloxane (antieczemic, anticoranary, antiantrogenic, and nematicide) .…”

Section: Resultsmentioning

confidence: 99%

“…The The values were the average of triplicate samples (n = 3) ± S.D., two-way analysis of variance (ANOVA) shows (P ≤ 0.05), so results are significant. biologically active geraniol, 59 grandisol (the boll weevil pheromone), 60 neric acid (a pheromone), 61 neophytadiene, 62 n-hexadecanoic acid, 63 phytol, 62 octadecanoic acid (antiinflammatory, antioxidant, anticancer), 64 hexacosene, 65 and nandrolone (anticancer) 66 were observed in the investigated ethanolic extract of C. citratus while its aqueous extract contained cyclopentasiloxane (antioxidant), 67 cis-linalool oxide (antifungal and antitermitic), 68 trans-linalool oxide (pyranoid), 69 pentasiloxane, 67 hexadecanoic acid, 63,67 and hexasiloxane (antieczemic, anticoranary, antiantrogenic, and nematicide). 70 Geraniol is the main bioactive component of C. citratus, 59 which shows a variety of activities including repellence to sand flies, mosquitoes, cattle ticks, 71 prevention of secondary complications in diabetes and reduction of hyperglycaemia, 72 anti-inflammatory and antioxidant properties, 73 antifungal activity, 74 activity against respiratory pathogens, skin and food-derived strains, potential against prostate/kidney/liver/bowel and skin cancer, 73 and antibacterial properties especially against B. subtilis (a pathogen of the bakery industry).…”

Section: ■ Results and Discussionmentioning

confidence: 99%

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Synergistic Antibacterial Screening of Cymbopogon citratus and Azadirachta indica: Phytochemical Profiling and Antioxidant and Hemolytic Activities

et al. 2023

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Current studies were performed to investigate the phytochemistry, synergistic antibacterial, antioxidant, and hemolytic activities of ethanolic and aqueous extracts of Azadirachta indica (EA and WA) and Cymbopogon citratus (EC and WC) leaves. Fourier transform infrared data verified the existence of alcoholic, carboxylic, aldehydic, phenyl, and bromo moieties in plant leaves. The ethanolic extracts (EA and EC) were significantly richer in phenolics and flavonoids as compared to the aqueous extracts (WA and WC). The ethanolic extract of C. citratus (EC) contained higher concentrations of caffeic acid (1.432 mg/g), synapic acid (6.743 mg/g), and benzoic acid (7.431 mg/g) as compared to all other extracts, whereas chlorogenic acid (0.311 mg/g) was present only in the aqueous extract of A. indica (WA). Food preservative properties of C. citratus can be due to the presence of benzoic acid (7.431 mg/g). Gas chromatography–mass spectrometry analysis demonstrated the presence of 36 and 23 compounds in A. indica and C. citratus leaves, respectively. Inductively coupled plasma analysis was used to determine the concentration of 26 metals (Al, As, B, Ba, Ca, Cd, Co, Cr, Cu, Fe, K, Mg, Mn, Mo, Na, Ni, Pb, Sb, Se, Si, Sn, Sr, V, Zn, Zr, Ti); the metal concentrations were higher in aqueous extracts as compared to the ethanolic extracts. The extracts were generally richer in calcium (3000–7858 ppm), potassium (13662–53,750 ppm), and sodium (3181–8445 ppm) and hence can be used in food supplements as a source of these metals. Antioxidant potential (DDPH method) of C. citratus ethanolic extract was the highest (74.50 ± 0.66%), whereas it was the lowest (32.22 ± 0.28%) for the aqueous extract of A. indica. Synergistic inhibition of bacteria (Staphylococcus aureus and Escherichia coli) was observed when the aqueous extracts of both the plants were mixed together in certain ratios (v/v). The highest antibacterial potential was exhibited by the pure extract of C. citratus, which was even higher than that of the standard drug (ciprofloxacin). The plant extracts and their mixtures were more active against S. aureus as compared to E. coli. No toxic hemolytic effects were observed for the investigated extracts indicating their safe medicinal uses for human beings.

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Section: Resultsmentioning

confidence: 99%

Section: ■ Results and Discussionmentioning

confidence: 99%

Synergistic Antibacterial Screening of Cymbopogon citratus and Azadirachta indica: Phytochemical Profiling and Antioxidant and Hemolytic Activities

et al. 2023

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“…For example, co-crystals with SA have been found with benzamide, 21,22 isonicotinamide, 22 carbamazepine, 23 sulfamethazine. 24 SA co-crystals with active pharmaceutically ingredients, APIs, also exist as exemplified by nandrolone 25 and olanzapine. 26 A number of co-crystals with AA can also be found in the literature, e.g.…”

Section: Introductionmentioning

confidence: 99%

Enantiotropic inconstancy, crystalline solid solutions and co-crystal in the salicylic acid–anthranilic acid system

Nordström

Mohajerani

Linehan

et al. 2022

Phys. Chem. Chem. Phys.

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“…Ini memungkinkan pada kokristalisasi padat molekular dengan interaksi antarmolekul kuat (seperti ikatan hidrogen) [42], [43]. Hal ini juga sudah dilaporkan bahwa penggilingan pada suhu di bawah suhu transisi gelas dari reaktan menghasilkan pembentukan fase amorf tetapi penggilingan pada suhu lebih tinggi dari suhu tersebut menyebabkan terbentuknya polimorf metastabil [44], [45], [46]. Hal tersebut telah dilakukan percobaan dengan menggiling karbamazepin dan sakarin di bawah suhu transisi gelas yang diharapkan menghasilkan campuran menginduksi pembentukan fase amorf [47], [48], [49].…”

Section: Mekanisme Kokristalisasi Pada Penggunaan Mekanokimiaunclassified

Review Pembuatan kokristalFarmasi Dengan Metode Mekanokimia

Yenti,

Zulhadjri,

Efdi

et al. 2023

Maj. Farmasetika

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Pengembangan bahan aktif farmasi saat ini cukup pesat, salah satunya adalah pengembangan kokristal. Kokristal dibuat dengan menggabungkan antara bahan aktif farmasi dan koformernya dengan berbagai metode misalnya pelarutan dan penggilingan. Mekanokimia adalah metode yang efektif untuk persiapan sistem kristal multikomponen. Mekanokimia dianggap sebagai alternatif pendekatan ramah lingkungan karena dilakukan dalam kondisi bebas pelarut atau dengan adanya pelarut dalam jumlah minimal. Artikel review ini dibuat dengan metode instrumen pencarian online terbitan internasional yang akan membahas definisi dan sejarah kokristal farmasi, teknik pembuatan kokristal, sejarah dan definisi mekanokimia, metode mekanokimia pada pembuatan kokristal farmasi, mekanisme metode mekanokimia, serta keuntungan dan kerugian metode mekanokimia. Oleh karena itu pada ulasan ini dijelaskan dan dibahas relevansi prosedur mekanokimia dalam pembentukan kristal multikomponen yang fokus pada kokristal farmasi. Selain itu pada akhir tinjauan ini juga dilaporkan ringkasan makalah ilmiah tentang sintesis mekanokimia kokristal farmasi.

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Synthesis of co-crystals of anti-cancer nandrolone as a potential leads towards treatment of cancer

Cited by 9 publications

References 28 publications

Synergistic Antibacterial Screening of Cymbopogon citratus and Azadirachta indica: Phytochemical Profiling and Antioxidant and Hemolytic Activities

Synergistic Antibacterial Screening of Cymbopogon citratus and Azadirachta indica: Phytochemical Profiling and Antioxidant and Hemolytic Activities

Enantiotropic inconstancy, crystalline solid solutions and co-crystal in the salicylic acid–anthranilic acid system

Review Pembuatan kokristalFarmasi Dengan Metode Mekanokimia

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