Synthesis of chlorogenic acid imprinted chromatographic packing by surface-initiated atom transfer radical polymerization and its application

Yuling, Niu; Ma, Min; Gong, Yafeng; Wang, Yue; Gong, Bolin

doi:10.1007/s40242-014-4201-0

Cited by 10 publications

(4 citation statements)

References 22 publications

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“…But as the nanotube length increases, the difference in translocation time of the polymer chain without and with HI becomes smaller and the more drag force gradually dominates the translocation process. Among the most fundamental quantities associated with translocation, the translocation time t c as a function of chain length N, t c -N α , is an important measure of the underlying dynamics [40,41] . Fig.9 shows the scaling exponent α as a function of velocity flux J for the plymer chain without and with HI at a chain length N=40 and nanotube length L=8.…”

Section: Translocation Timementioning

confidence: 99%

Effect of hydrodynamic interaction on flow-induced polymer translocation through a nanotube

Ding

Duan

Yuyuan

et al. 2015

Chem. Res. Chin. Univ.

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We investigated the effect of hydrodynamic interaction(HI) on flow-induced polymer translocation through a nanotube by Brownian dynamics simulations. Whether there is HI in the simulation system is separately controlled by using different diffusion tensors. It is found that HI has no effect on critical velocity flux for long polymer chains due to the competition between more drag force and the hindrance of chain stretching from HI, however, HI broadens the transition interval. In addition, for flow-induced polymer translocation with HI, the critical velocity flux firstly slowly decreases with the increase of chain length and then becomes identical to that of it without HI, that is, the critical velocity flux is independent of chain length. At the same time, HI also accelerates the translocation process and makes the relative variation amplitude of single bead translocation time smaller. In fact, HI can enhance the intrachain cooperativity to make the whole chain obtain more drag force from fluid field and hinder chain stretching, both of which play an important role in translocation process.

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Section: Translocation Timementioning

confidence: 99%

Effect of hydrodynamic interaction on flow-induced polymer translocation through a nanotube

Ding

Duan

Yuyuan

et al. 2015

Chem. Res. Chin. Univ.

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“…It was previously reported that 4‐VP was the functional monomer of choice for sinapic acid structural analogues (caffeic acid and chlorogenic acid) due to the basic nature of this monomer, which enhances its interactions with acidic template molecules . The number of intermolecular hydrogen bonds that can be formed between the template molecule and functional monomer determines the complex level in the computational screening .…”

Section: Resultsmentioning

confidence: 99%

Isolation of sinapic acid from broccoli using molecularly imprinted polymers

Hosny

Gohary

Saad

et al. 2018

J of Separation Science

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A molecularly imprinted polymer was synthesized for the purpose of sinapic acid isolation from Egyptian nutraceutical Botrytis italica, L. (broccoli) due to its prominent medicinal and wide pharmacological activities. A computational study was first developed to determine the optimal template to functional monomer molar ratio. Based on the computational results, five polymers were synthesized using a bulk polymerization method with sinapic acid as the template molecule. Evaluation of the synthesized polymers binding performance was carried out using batch rebinding assay, which revealed that the molecularly imprinted polymer of molar ratio (1:4:20), template to functional monomer (4-vinyl pyridine) to crosslinker (ethylene glycol dimethacrylate) was of optimum performance, thus, this polymer was applied for sinapic acid isolation from closely related analogues. This represents a more practical approach to isolate sinapic acid from different natural extracts selectively.

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“…Firstly, 5.0 g of 5 µm silica particles were hydrolyzed in 68 mL of 10% hydrochloric acid at 130 °C under stirring reflux for 12 h. The hydrolyzed silica particles were then filtered, washed with water until neutralized, and dried under vacuum at 110 °C for 24 h [34]. Second, 3.0 g of hydrolyzed silica particles, 60 mL of toluene and 6 mL of APTES were placed in a 250 mL flask.…”

Section: Methodsmentioning

confidence: 99%

Glycopolymer Grafted Silica Gel as Chromatographic Packing Materials

Luo

Sun

et al. 2018

IJMS

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The modification of the surface of silica gel to prepare hydrophilic chromatographic fillers has recently become a research interest. Most researchers have grafted natural sugar-containing polymers onto chromatographic surfaces. The disadvantage of this approach is that the packing structure is singular and the application scope is limited. In this paper, we explore the innovative technique of grafting a sugar-containing polymer, 2-gluconamidoethyl methacrylamide (GAEMA), onto the surface of silica gel by atom transfer radical polymerization (ATRP). The SiO2-g-GAEMA with ATRP reaction time was characterized by Fourier infrared analysis, Thermogravimetric analysis (TGA), and elemental analysis. As the reaction time lengthened, the amount of GAEMA grafted on the surface of the silica gel gradually increased. The GAEMA is rich in amide bonds and hydroxyl groups and is a typical hydrophilic chromatography filler. Finally, SiO2-g-GAEMA (reaction time = 24 h) was chosen as the stationary phase of the chromatographic packing and evaluated with four polar compounds (uracil, cytosine, guanosine, and cytidine). Compared with unmodified silica gel, modified silica gel produces sharper peaks and better separation efficiency. This novel packing material may have a potential for application with highly isomerized sugar mixtures.

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Synthesis of chlorogenic acid imprinted chromatographic packing by surface-initiated atom transfer radical polymerization and its application

Cited by 10 publications

References 22 publications

Effect of hydrodynamic interaction on flow-induced polymer translocation through a nanotube

Effect of hydrodynamic interaction on flow-induced polymer translocation through a nanotube

Isolation of sinapic acid from broccoli using molecularly imprinted polymers

Glycopolymer Grafted Silica Gel as Chromatographic Packing Materials

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