Synthesis of Chitosan-Polyvinyl Alcohol Copolymers for Smart Drug Delivery Application

Abstract

Chitosan is a natural polymer obtained from exoskeletons of crustaceans and polyvinyl alcohol (PVA) is a synthetic polymer which has excellent film forming ability along with non-toxic nature. The current work focuses on synthesizing a smart polymer by copolymerization of natural and synthetic polymers and exploring its applications in drug delivery. The copolymers were blended in different ratios and were synthesized using ammonium ceric nitrate as initiator and glutaraldehyde as a crosslinking agent which were converted to films by casting method. Amoxicillin, as a model drug was incorporated to the copolymerized films to study the in-vitro drug release. The films obtained were evaluated by varying the pH to study the pH responsive nature of films. Drug release studies were performed to obtain the release profile of drug; water uptake capacity of the copolymerized film were measured to determine the swelling behaviour of the films. The films were further characterized using Fourier Transform Infrared Spectroscopy (FTIR), Scanning Electron Microscopy (SEM) and Differential Scanning Calorimetry (DSC) to identify the structural and morphological changes along with thermal transitions. The results indicate that the synthesized copolymers are pH responsive in nature having great potential for application in controlled and targeted drug delivery.

Safe and flexible chitosan‐based polymer gel as an electrolyte for use in zinc‐alkaline based chemistries

“…Analysis of the chitosan spectra shows peaks around 3421-3300 cm −1 that represents a strong O H bond and its axial stretch due to the presence of an alcohol group. 42,43 The peak around 2926 cm −1 indicates medium C H stretch in alkanes, and the peak at 1687 cm −1 indicates medium N H stretch bend due to the amine group of chitosan. 42 Peaks around 1442 and 1480 cm −1 indicate the C H stretching of CH 2 and CH 3 groups.…”

“…42,43 The peak around 2926 cm −1 indicates medium C H stretch in alkanes, and the peak at 1687 cm −1 indicates medium N H stretch bend due to the amine group of chitosan. 42 Peaks around 1442 and 1480 cm −1 indicate the C H stretching of CH 2 and CH 3 groups. The small, tiny peaks around 1296 cm −1 are due to the strong C N stretch present in amines.…”

“…Further, the addition of 30 wt% KOH (0.3 ratio) to CP0.2 indicated re-emergence of few characteristic peaks between 1023 and 1158 cm −1 . Also, small disturbances in between the characteristic peaks indicating vibrations [41][42][43] in bonds were observed. Overall, the FTIR spectra results are indicative of changes in all the samples pertaining to the effect of different additives.…”

Wound healing improvement by curcumin‐loaded electrospun nanofibers and BFP‐MSCs as a bioactive dressing

“…We evaluated the wound‐healing potential of Cur‐incorporated CS/PVA nanofibers in a combinational composite and their interaction with carbopol/PCL fibers. Recently, CS/PVA electrospun nanofiber was introduced as a suitable drug delivery system . Charernsriwilaiwat et al reported that CS‐EDTA/PVA as biodegradable, biocompatible and antibacterial nanofiber mats can be applied to wounds as dressing materials .…”

Synthesis, characterization, and drug release activity of structurally modified poly(vinyl alcohol)

“…The structure of PVA was modified with 4‐maleiidohenylisocyanate and its thermal and mechanical properties were tested . Similarly, the structure of PVA was modified with chitosan, rifambin, glycidylmethacrylate, glycoside, N ‐alkyl‐substituted carbamates, 3‐diethylaminopropylamine, succinimide, propargylamine, poly(ɛ‐caprolactone), diethylchlorophosphate, soy bean oil triglycerides, and natural rubber latex for various end user applications. In 2010, Wang and Hsieh modified the structure of PVA with PEG diacrylchloride.…”