Synthesis of chitosan aerogels as promising carriers for drug delivery: A review

Shi, Wei; Ching, Yern Chee; Chuah, Cheng Hock

doi:10.1016/j.carbpol.2019.115744

Cited by 189 publications

(71 citation statements)

References 152 publications

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“…The presence of a large number of valuable free primary amino groups increases the hydrophilic nature of the chitosan in an aqueous solution in which aids its interaction with the nanoparticles, polymers, cells, and drugs. Moreover, chitosan biopolymers as sustainable chitin derivatives have been extensively scrutinized in the biomedical industry due to intriguing features such as biocompatibility, low allergenicity, biodegradability, and non-toxicity 12 , 13 . More specifically, literature has been overwhelmed with a variety of reports referring to the multiple roles of chitosan in nanoparticles synthesis, stabilization, and their applications 14 , 15 .…”

Section: Introductionmentioning

confidence: 99%

Synergistic effects of combinatorial chitosan and polyphenol biomolecules on enhanced antibacterial activity of biofunctionalized silver nanoparticles

Rezazadeh

Buazar

Matroodi

2020

Sci Rep

120

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The present study reports the synergistic antibacterial activity of biosynthesized silver nanoparticles (AgNPs) with the aid of a combination of chitosan and seaweed-derived polyphenols as a green synthetic route. Under optimum synthesis conditions, the rapid color change from yellowish to dark brown and UV–visible absorption peak at 425 confirmed the initial formation of AgNPs. DLS, TEM, XRD, and EDX analyses revealed the spherical shape of pure biogenic AgNPs with a mean diameter size of 12 nm ± 1.5 nm, and a face-centered cubic crystal structure, respectively. FTIR and TGA results indicated the significant contribution of chitosan and polyphenol components into silver ions bioreduction and thermal stability of freshly formed AgNPs. Long-term colloidal stability of AgNPs was obtained after 6-month storage at room temperature. The bio-prepared AgNPs possessed a negative surface charge with a zeta potential value of − 27 mV. In contrast to naked chemical silver nanoparticles, the green Ag nanosamples demonstrated the distinct synergistic antibacterial in vitro toward all selected human pathogens presumably due to the presence of high content of biomolecules on their surface. The results show that synergy between chitosan and polyphenol results in the enhancement of bactericidal properties of biogenic AgNPs. We also highlighted the underlying mechanism involved in AgNPs formation based on nucleophile–electrophile interaction.

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Section: Introductionmentioning

confidence: 99%

Synergistic effects of combinatorial chitosan and polyphenol biomolecules on enhanced antibacterial activity of biofunctionalized silver nanoparticles

Rezazadeh

Buazar

Matroodi

2020

Sci Rep

120

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“…Firstly, this might be related with the number of microvoids on the surface of the composites which would facilitate the water transfer [48][49][50], as verified by the SEM graphs. Next, the interactions between lipid phase and biopolymer chains in o/w emulsion films might just increase the external tortuousness and take negligible effect on the moisture barrier of emulsified films [51][52][53][54]. In the end, EO and Tween 80 might increase the free volume among starch chains due to their plasticization effect, which facilitated the water transfer [55,56].…”

Section: Wvpmentioning

confidence: 99%

Preparation and Characterization of Starch/Empty Fruit Bunch-Based Bioplastic Composites Reinforced with Epoxidized Oils

et al. 2020

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This study examined the development of starch/oil palm empty fruit bunch-based bioplastic composites reinforced with either epoxidized palm oil (EPO) or epoxidized soybean oil (ESO), at various concentrations, in order to improve the mechanical and water-resistance properties of the bio-composites. The SEM micrographs showed that low content (0.75 wt%) of epoxidized oils (EOs), especially ESO, improved the compatibility of the composites, while high content (3 wt%) of EO induced many voids. The melting temperature of the composites was increased by the incorporation of both EOs. Thermal stability of the bioplastics was increased by the introduction of ESO. Low contents of EO led to a huge enhancement of tensile strength, while higher contents of EO showed a negative effect, due to the phase separation. The tensile strength increased from 0.83 MPa of the control sample to 3.92 and 5.42 MPa for the composites with 1.5 wt% EPO and 0.75 wt% ESO, respectively. EOs reduced the composites’ water uptake and solubility but increased the water vapor permeability. Overall, the reinforcing effect of ESO was better than EPO. These results suggested that both EOs can be utilized as modifiers to prepare starch/empty-fruit-bunch-based bioplastic composites with enhanced properties.

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“…(Bmim)(Cl) has been used as an environmentally friendly solvent to prepare chitosan/cellulose biocomposites sorbents for industrial effluent treatments [22]. Moreover, due to its strong interactions with negatively charged entities, including lipids and proteins, IL/chitosan-based aerogels are used to stabilize the complexes, with DNA fragments being good choices for gene delivery systems [66].…”

Section: Chitosanmentioning

confidence: 99%

Marine-Derived Polymers in Ionic Liquids: Architectures Development and Biomedical Applications

et al. 2020

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Marine resources have considerable potential to develop high-value materials for applications in different fields, namely pharmaceutical, environmental, and biomedical. Despite that, the lack of solubility of marine-derived polymers in water and common organic solvents could restrict their applications. In the last years, ionic liquids (ILs) have emerged as platforms able to overcome those drawbacks, opening many routes to enlarge the use of marine-derived polymers as biomaterials, among other applications. From this perspective, ILs can be used as an efficient extraction media for polysaccharides from marine microalgae and wastes (e.g., crab shells, squid, and skeletons) or as solvents to process them in different shapes, such as films, hydrogels, nano/microparticles, and scaffolds. The resulting architectures can be applied in wound repair, bone regeneration, or gene and drug delivery systems. This review is focused on the recent research on the applications of ILs as processing platforms of biomaterials derived from marine polymers.

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Synthesis of chitosan aerogels as promising carriers for drug delivery: A review

Cited by 189 publications

References 152 publications

Synergistic effects of combinatorial chitosan and polyphenol biomolecules on enhanced antibacterial activity of biofunctionalized silver nanoparticles

Synergistic effects of combinatorial chitosan and polyphenol biomolecules on enhanced antibacterial activity of biofunctionalized silver nanoparticles

Preparation and Characterization of Starch/Empty Fruit Bunch-Based Bioplastic Composites Reinforced with Epoxidized Oils

Marine-Derived Polymers in Ionic Liquids: Architectures Development and Biomedical Applications

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