Synthesis of chiral β-chalcogen amine derivatives and Gram-positive bacteria activity

Vargas, J. Ramón; Narayanaperumal, Senthil; Gul, Kashif; Ravanello, Bruno B.; Dornelles, Luciano; Soares, Letiére C.; Alves, Camilla F.S.; Schneider, Taiane; Vaucher, Rodrigo de Almeida; Santos, Roberto C.V.; Rodrigues, Oscar E. D.

doi:10.1016/j.tet.2012.09.049

Cited by 20 publications

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“…For instance, antiviral, antimicrobial, antioxidant and antitumoral are some of the properties related to molecules containing a chalcogenium atom. [9][10][11][12] Despite the prominent importance of nucleosides and chalcogenium compounds, methodologies for preparing chalcogeno-nucleosides are rarely reported and still very limited compared to their isolated counterparts. Consequently, protocols seeking chalcogenium introduction in nucleosides or selective modifications of chalcogeno-nucleoside molecules are a component of an important research field for the preparation of new libraries of organochalcogenium molecules with potential biological effects.…”

Section: Introductionmentioning

confidence: 99%

Synthesis, antioxidant and antitumoral activities of 5′-arylchalcogeno-3-aminothymidine (ACAT) derivatives

et al. 2017

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This article presents the preparation and biological activities of new 5'-arylchalcogeno-3-aminothymidine derivatives as antioxidants (inhibition of lipid peroxidation, scavenging of the free radical 2,2-diphenylpicrylhydrazyl and demonstration of a thiol peroxidase-like activity) as well as antitumoral agents against bladder carcinoma 5637. The chalcogeno-aminothymidines presented prominent activity in the tests for both biological properties, showing a direct relation with the chalcogenium atom.

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Section: Introductionmentioning

confidence: 99%

Synthesis, antioxidant and antitumoral activities of 5′-arylchalcogeno-3-aminothymidine (ACAT) derivatives

et al. 2017

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“…As part of our growing interest in using α-amino acids as chiral building blocks in organic synthesis [21,[38][39][40][41][42][43][44][45] and in connection with the increasing importance of the synthesis of small libraries of compounds with programmed variations of substituents, we describe herein an assay, an inexpensive synthetic route for the preparation of a set of chiral Nprotected α-amino acids-derived 1,2,4-oxadiazoles under microwave irradiation, as depicted in Scheme 1.…”

Section: Introductionmentioning

confidence: 99%

A Straightforward and High-Yielding Synthesis of 1,2,4-Oxadiazoles from Chiral N-Protected α-Amino Acids and Amidoximes in Acetone-Water: An Eco-Friendly Approach

Sauer

Wolf

Quoos

et al. 2019

Journal of Chemistry

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Synthesis of Biologically Relevant Small Molecules Containing Selenium. Part C. Miscellaneous Biological Activities

Braga

Rafique

2014

Patai's Chemistry of Functional Groups

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Organoselenium compounds are known as antioxidants, antithyroid, antinociceptive, antidepressant, thioredoxin reductase (TrxR) mimetic agents with a variety of protective behaviors (e.g. cardioprotective, neuroprotective and hepatoprotective). In addition. they can be used as virueides, bactericides, fungicides, cytokine inducers and immunomodulators. The chemical and biological activity of organose leniumcompounds is discussed herein. The strategies and methods for the preparation of biologically relevant small molecules containing selenium are reviewed in this chapter. The unique redox properties of selenium confer catalytic activity to organoselenium compounds and influence their biological properties as well as the methods selected for their preparation. The approaches available to obtain organoselenium compounds, including reaction of elemental selenium or diselenides with different types of carbanions or reaction of organic electrophiles with selenolate anions generated by different methods, are disclosed in this chapter.

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Synthesis of chiral β-chalcogen amine derivatives and Gram-positive bacteria activity

Cited by 20 publications

References 73 publications

Synthesis, antioxidant and antitumoral activities of 5′-arylchalcogeno-3-aminothymidine (ACAT) derivatives

Synthesis, antioxidant and antitumoral activities of 5′-arylchalcogeno-3-aminothymidine (ACAT) derivatives

A Straightforward and High-Yielding Synthesis of 1,2,4-Oxadiazoles from Chiral N-Protected α-Amino Acids and Amidoximes in Acetone-Water: An Eco-Friendly Approach

Synthesis of Biologically Relevant Small Molecules Containing Selenium. Part C. Miscellaneous Biological Activities

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