Synthesis of chiral binaphthol-based bishydroxylamines

Abstract

Although bishydroxylamines have been widely used in chemistry, very little has been reported on corresponding chiral representatives. In this paper, we present the synthesis of two chiral binaphthyl-based bishydroxylamines with different substitution patterns at their NOH functions. The key step of the synthesis involves the reduction of the corresponding dinitrone compounds. The molecular structure in the solid state of one of the nitrone precursors is presented.