Synthesis of Chiral 1,2-Amino Alcohol-Containing Compounds Utilizing Ruthenium-Catalyzed Asymmetric Transfer Hydrogenation of Unprotected α-Ketoamines
Hari P. R. Mangunuru,
Leila Terrab,
Venumadhav Janganati
et al.
Abstract:Herein, we disclose a facile synthetic strategy to access an important class of drug molecules that contain chiral 1,2amino alcohol functionality utilizing highly effective rutheniumcatalyzed asymmetric transfer hydrogenation of unprotected αketoamines. Recently, the COVID-19 pandemic has caused a crisis of shortage of many important drugs, especially norepinephrine and epinephrine, for the treatment of anaphylaxis and hypotension because of the increased demand. Unfortunately, the existing technologies are no… Show more
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