Synthesis of chalcones catalyzed by aminopropylated silica sol–gel under solvent-free conditions

Synthesis of Biologically Active Chalcon Analogues via Claisen-Schmidt Condensation in Solvent-Free Conditions: Supported Mixed Addenda Heteropoly Acid as a Heterogeneous Catalyst

“…The solvent of the filtrate was evaporated then followed by chromatography to obtained pure products. Spectroscopic data of the products matched well with those in the literature [20][21][22][23] …”

Synthesis and Biological Activity of Novel 2,5-Dichloro-3-Acetylthiophene Chalcone Derivatives

“…All compounds (1)(2)(3)(4)(5)(6)(7)(8)(9)(10)(11)(12)(13)(14)(15)(16)(17)(18)(19)(20) were synthesized by a mixture of 2,5-dichloro-3-acetylthiophene (0.001 mol) and the appropriate aryl or heteroaryl aldehyde (0.001 mol) were stirred in methanol (10 mL). To this mixture an aqueous solution of KOH (40%, 5 mL) was added with continuous stirring.…”

“…Then, it was purified by column chromatography and crystallized from a mixture of ethyl acetate and hexane (1:1) (Scheme-I). Reagents and conditions: (i) potassium hydroxide (KOH), (ii) Room temperature condition; (iii) Methanol; The structural group of R in scheme-1 is specified below (1)(2)(3)(4)(5)(6)(7)(8)(9)(10)(11)(12)(13)(14)(15)(16)(17)(18)(19)(20) and the synthesis was carried out with individual type of aromatic or heteroaromatic aldehydes to synthesize various chalcone derivatives with 2,5-dichloro-3-acetylthiopene ring (1)(2)(3)(4)(5)(6)(7)(8)(9)(10)(11)(12)(13)(14)(15)(16)(17)(18)(19)(20) as in the Table 1. The mechanism of formation of novel synthetic chalcone was shown below in Figure 1.…”

“…The MIC was taken as that concentration used in the test tube number just prior to the test tube number labelled where the first sign of growth was observed. This procedure was followed to determine the MIC values for all the compounds of series of new chalcone derivatives with 2,5-dichloro-3-acetylthiopene ring (1)(2)(3)(4)(5)(6)(7)(8)(9)(10)(11)(12)(13)(14)(15)(16)(17)(18)(19)(20). It is shown in the Table 2.…”

An Overview on Cardamonin

“…3A) of an aldehyde and a ketone followed by dehydration. 2,[14][15][16] There are also articles based on the Suzuki reaction 17,18 and an interesting example of chalcone synthesis (including cardamonin) that can be found in literature using a bromomagnesium salt. 19 Of course, naturally occurring synthesis is chemically more complex and involves several enzymes.…”