Synthesis of certain substituted quinoxalines as antimicrobial agents (part II)

Abstract

Several fused triazolo and ditriazoloquinoxaline derivatives such as 1-aryl-4-chloro-[1,2,4]triazolo[4,3-a]quinoxalines (3a-d), 4-alkoxy[1,2,4]triazolo[4,3-a]quinoxalines (4a,b), 4-substituted-amino-[1,2,4] triazolo[4,3-a]quinoxalines (5a-h), 1-(aryl)-[1,2,4]triazolo[4,3-a]quinoxalin-4(5H)-thione (6), 4-(arylidenehydrazino)1-phenyl-[1,2,4]triazolo[4,3-a]quinoxalines (10a-e) and [1,2,4]ditriazolo[4,3-a:3',4'-c]quinoxaline derivatives (11-13) have been synthesized and some of these derivatives were evaluated for antimicrobial and antifungal activity in vitro. It was found that compounds 3a and 9b possess potent antibacterial activity compared to the standard tetracycline.

Synthesis and Biological Evaluation of New Heteroaryl Carboxylic Acid Derivatives as Anti-inflammatory-Analgesic Agents

“…20) Hydrolysis of the chloropyridazine derivatives 3a, b was carried out upon heating in acetic acid to afford the corresponding 3(2H)-pyridazinone derivatives 5a, b. Furthermore, 3-(6-ethoxypyridazinamino) benzoic acids 6a, b were synthesized by heating 3a, b in absolute ethanol in the presence of sodium ethoxide.…”

Design, Synthesis and Biological Evaluation of Some Novel 3-Methlyquinoxaline-2-Hydrazone Derivatives

“…Quinoxaline, or 1,4-benzo[pyrazine is an important structural unit among nitrogencontaining heterocyclic compounds. Quinoxalines are, in general, easy to prepare and numerous derivatives have been reported in the literature because of their biological activity, specifically as antimicrobial [2][3][4][5][6][7][8], antibacterial [9][10][11], anti-cancer [12], antiaminoceptive [13], anti-inflammatory [14,15] anti-viral [16][17][18], antimalaria [19] agents. They possess well known biological activities including AMPA/GlyN receptor antagonist [20], antihistaminic agents [21], anti-trypanosomal activity [22], anti-herps, trypanocida, antiplasmodial activity [23], Ca 2+ uptake/release inhibitor [24], and inhibitor of vascular smooth muscle cell proliferation.…”

Synthetic Methods and Exploring Biological Potential of Various Substituted Quinoxalin-2-one Derivatives

“…Quinoxaline and its derivatives are mostly of synthetic origin. Substituted quinoxalines are an important class of benzoheterocycles, which constitute the building blocks of wide range of pharmacologically active compounds having antibacterial [1][2][3][4] antifungal [5], anticancer [6,7], antitubercular [8], antileishmanial [9], antimalarial [10] and antidepressant activities [11]. Also, some quinoxalin-2-ones and quinoxaline-2,3-diones have been reported to show antimicrobial [12,13], potent antithrombotic [14], anti-pain and antiinflammatory [15] activities.…”

“…Quinoxaline and its derivatives are mostly of synthetic origin. Substituted quinoxalines are an important class of benzoheterocycles, which constitute the building blocks of wide range of pharmacologically active compounds having antibacterial [1][2][3][4] [15] activities. The quinoxaline is described as a bioisoster of quinoline, naphthalene, benzothiophene and other aromatic rings such as pyridine and pyrazine.…”