Synthesis of carboxymethyl Xanthan/ double-walled carbon nanotube hybrid hydrogel nanocomposite for transdermal release of drug

Stasaid, Maroua; Boutemak, Khalida; Ibtissem, Lahcene; Flahaut, Emmanuel; Zafour, Amel Hadj-Ziane

doi:10.1080/1539445x.2021.1943682

Cited by 4 publications

(2 citation statements)

References 48 publications

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“…The encapsulation efficiency of the diclofenac was increased to 75%, and the sustained release of the drug was observed due to the presence of nanotubes. The composite was stable in extreme conditions similar to that which may be present on the skin [ 76 ]. For the delivery of lornoxicam-loaded thiolated XG as a topical gel formulation, it was synthesised by the microwave esterification reaction.…”

Section: Xg-based Systems For the Delivery Of Drugsmentioning

confidence: 99%

Advances in Xanthan Gum-Based Systems for the Delivery of Therapeutic Agents

et al. 2023

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In the last three decades, polymers have contributed significantly to the improvement of drug delivery technologies by enabling the controlled and sustained release of therapeutic agents, versatility in designing different delivery systems, and feasibility of encapsulation of both hydrophobic and hydrophilic molecules. Both natural and synthetic polymers have been explored for the delivery of various therapeutic agents. However, due to the disadvantages of synthetic polymers, such as lack of intrinsic biocompatibility and bioactivity, hydrophobicity, and expensive and complex procedure of synthesis, there is a move toward the use of naturally occurring polymers. The biopolymers are generally derived from either plants or microorganisms and have shown a wide range of applications in drug administration due to their hydrophilic nature, biodegradability, biocompatibility, no or low toxicity, abundance, and readily available, ease of chemical modification, etc. This review describes the applications of a biopolymer, xanthan gum (XG), in the delivery of various therapeutic agents such as drugs, genetic materials, proteins, and peptides. XG is a high molecular weight, microbial heteropolysaccharide and is produced as a fermented product of Gram-negative bacteria, Xanthomonas campestris. Traditionally, it has been used as a thickener in liquid formulations and an emulsion stabiliser. XG has several favourable properties for designing various forms of drug delivery systems. Furthermore, the structure of XG can be easily modified using different temperature and pH conditions. Therefore, XG and its derivatives have been explored for various applications in the food, pharmaceutical, and cosmetic industries.

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Section: Xg-based Systems For the Delivery Of Drugsmentioning

confidence: 99%

Advances in Xanthan Gum-Based Systems for the Delivery of Therapeutic Agents

et al. 2023

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“…Different methodologies were proposed for the fabrication of hybrid hydrogels (HG NT ) based on the incorporation of MWCNT into the polymer networks [33][34][35]. Here, we used a previously reported strategy based on a modified "grafting from" approach involving the co-polymerization of Gelatin (Gel) coated MWCNT (Gel@MWCNT) in the presence of AAm and EBA as plasticizing and crosslinking monomers, respectively.…”

Section: Synthesis and Characterization Of Hybrid Hydrogelsmentioning

confidence: 99%

Carbon Nanotubes Hybrid Hydrogels for Environmental Remediation: Evaluation of Adsorption Efficiency under Electric Field

et al. 2021

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The performance of Carbon Nanotubes hybrid hydrogels for environmental remediation was investigated using Methylene Blue (MB), Rhodamine B (RD), and Bengal Rose (BR) as model contaminating dyes. An acrylate hydrogel network with incorporated CNT was synthesized by photo-polymerization without any preliminary derivatization of CNT surface. Thermodynamics, isothermal and kinetic studies showed favorable sorption processes with the application of an external 12 V electric field found to be able to influence the amount of adsorbed dyes: stronger interactions with cationic MB molecules (qexp and qexp12 of 19.72 and 33.45 mg g−1, respectively) and reduced affinity for anionic RD (qexp and qexp12 of 28.93 and 13.06 mg g−1, respectively) and neutral BR (qexp and qexp12 of 36.75 and 15.85 mg g−1, respectively) molecules were recorded. The influence of pH variation on dyes adsorption was finally highlighted by reusability studies, with the negligible variation of adsorption capacity after five repeated sorption cycles claiming for the suitability of the proposed systems as effective sorbent for wastewater treatment.

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Hybrid nanocomposite materials

Alarifi,

Asmatulu

2023

Advanced Hybrid Composite Materials and Their Applications

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Synthesis of carboxymethyl Xanthan/ double-walled carbon nanotube hybrid hydrogel nanocomposite for transdermal release of drug

Cited by 4 publications

References 48 publications

Advances in Xanthan Gum-Based Systems for the Delivery of Therapeutic Agents

Advances in Xanthan Gum-Based Systems for the Delivery of Therapeutic Agents

Carbon Nanotubes Hybrid Hydrogels for Environmental Remediation: Evaluation of Adsorption Efficiency under Electric Field

Hybrid nanocomposite materials

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