Synthesis of carboxymethyl chitosan-strontium complex and its therapeutic effects on relieving osteoarthritis

Zheng-wei, Liu; Mo, Xiaoqiong; Ma, Fenbo; Li, Sijing; Wu, Guofeng; Tang, Bin

doi:10.1016/j.carbpol.2021.117869

Cited by 11 publications

(11 citation statements)

References 31 publications

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“…Thus, Liu et al synthesized carboxymethyl chitosan-strontium complex (CMCS-Sr) and found that the complex can promote the secretion of type II collagen (COL-II) to facilitate chondrocyte proliferation, while significantly down-regulating the expression of IL-1β, IL-6, and MMP-9 genes, thus confirming the positive antiapoptotic and antiinflammatory effects of this complex with the potential to alleviate OA. 117 Magnesium has been found as another indispensable trace element for the human body. As a mediator of pain and inflammation, it can help change the levels of inflammatory cytokines in human and animal models.…”

Section: ■ Synthesis Methods Of Polysaccharide Metal Complexesmentioning

confidence: 99%

“…Chitosan and its derivatives also exert a positive effect on cartilage repair. Thus, Liu et al synthesized carboxymethyl chitosan-strontium complex (CMCS-Sr) and found that the complex can promote the secretion of type II collagen (COL-II) to facilitate chondrocyte proliferation, while significantly down-regulating the expression of IL-1β, IL-6, and MMP-9 genes, thus confirming the positive antiapoptotic and anti-inflammatory effects of this complex with the potential to alleviate OA …”

Section: Physico-chemical Characterizationmentioning

confidence: 98%

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Synthesis, Characterization, and Bioactivities of Polysaccharide Metal Complexes: A Review

Jiang

et al. 2022

J. Agric. Food Chem.

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Natural polysaccharides are critical to a wide range of fields (e.g., medicine, food production, and cosmetics) for their various remarkable physical properties and biological activities. However, the bioactivities of naturally acquired polysaccharides may be unsatisfactory and limit their further applications. It is generally known that the chemical structure exhibited by polysaccharides lays the material basis for their biological activities. Accordingly, possible structural modifications should be conducted on polysaccharides for their enhancement. Recently, polysaccharides complexed with metal ions (e.g., Fe, Zn, Mg, Cr, and Pt) have been reported to be possibly used to improve their bioactivities. Moreover, since the properties exhibited by metal ions are normally conserved, polysaccharides may be endowed with new applications. In this review, the synthesis methods, characterization methods, and bioactivities of polysaccharide metal complexes are summarized specifically. Then, the application prospects and limitations of these complexes are analyzed and discussed.

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Section: ■ Synthesis Methods Of Polysaccharide Metal Complexesmentioning

confidence: 99%

Section: Physico-chemical Characterizationmentioning

confidence: 98%

Synthesis, Characterization, and Bioactivities of Polysaccharide Metal Complexes: A Review

Jiang

et al. 2022

J. Agric. Food Chem.

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“…SEM revealed that CMCS physically blocking paper fiber pores generated a film (Figure S13B), which improved the loading efficiency of DNAzyme and OPD to a certain extent. Meanwhile, the FT-IR spectra (Figure S14) of the CMCS modified paper indicated the absorption band at 1595 and 1427 cm –1 attributed to stretching vibrations of asymmetric and symmetric carboxylic groups . It was the electrostatic interactions between positively charged protonated amine groups from OPD and negatively charged deprotonated hydroxyl groups from CMCS that prevented OPD from washout from the detection spot by sample flowing.…”

Section: Resultsmentioning

confidence: 99%

“…Meanwhile, the FT-IR spectra (Figure S14) of the CMCS modified paper indicated the absorption band at 1595 and 1427 cm −1 attributed to stretching vibrations of asymmetric and symmetric carboxylic groups. 36 It was the electrostatic interactions between positively charged protonated amine groups from OPD and negatively charged deprotonated hydroxyl groups from CMCS that prevented OPD from washout from the detection spot by sample flowing. Thus, the colorimetric signals containing CMCS treatment could distinguish a lower concentration of the target, providing a higher sensitivity even with the naked eye.…”

Section: ■ Introductionmentioning

confidence: 99%

Target-Responsive Smart Nanomaterials via a Au–S Binding Encapsulation Strategy for Electrochemical/Colorimetric Dual-Mode Paper-Based Analytical Devices

et al. 2022

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Target-responsive nanomaterials attract growing interest in the application of drug delivery, bioimaging, and sensing due to the responsive releasing of guest molecules by the smart molecule gate. However, it remains a challenge to develop smart nanomaterials with simple assembly and low nonspecific leakage starting from encapsulation strategies, especially in the sensing field. Herein, Au nanoclusters (Au NCs) were first grown on porous carbon derived from ZIF-8 (PCZIF) to be employed as nanocarriers. By employing the Au NCs as linkers and aptamer (Apta) double-strand hybrids (target Apta and SH-complementary DNA) as capping units, we reported the novel target-responsive nanomaterials of Apta/Au NCs-PCZIF/hemin through Au–S binding encapsulation for sensing assays. The Au–S binding encapsulation strategy simplified the packaging procedure and reduced non-target responsive leakage. As a proof, ochratoxin A (OTA) as a model target participates in the double-strand hybrid competitive displacement reaction and triggered Apta conformation switches from a coil to a G-quadruplex structure accompanied by the dissociation of the gatekeeper. Simultaneously, the released hemin can initiate a self-assembly to form G-quadruplex/hemin DNAzyme. Interestingly, owing to DNAzyme providing electron transfer mediators and peroxidase-like activity, we proposed an electrochemical/colorimetric dual-mode paper-based analytical device (PAD) that provided self-verification to enhance reliability and accuracy, benefiting from independent signal conversion and transmission mechanism. As a consequence, the proposed dual-mode PAD could achieve sensitive electrochemical detection and visual prediction of OTA in the range of 1 pg/mL to 500 ng/mL and 50 pg/mL to 500 ng/mL, respectively. The electrochemical detection limit for OTA was as low as 0.347 pg/mL (S/N = 3). We believe that this work provides point-of-care testing (POCT) tools for a broad spectrum of applications.

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“…[17][18][19] Research showed that CMCS and strontium ions could form a new polysaccharide complex that could promote the secretion of type II collagen and effectively reduce articular cartilage damage and subchondral bone degradation. 20 Locust bean gum (LBG) is a high molecular weight branched polysaccharide obtained from carob trees. 21 LBG belongs to a family of galactomannan containing a structure of (1-4)-b-D-mannopyranosyl backbone with an attachment of (1-6)-a-D-galactose single units.…”

Section: Introductionmentioning

confidence: 99%

A photocrosslinked methacrylated carboxymethyl chitosan/oxidized locust bean gum double network hydrogel for cartilage repair

Cheng,

Peng,

Luo

et al. 2023

J. Mater. Chem. B

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Synthesis of carboxymethyl chitosan-strontium complex and its therapeutic effects on relieving osteoarthritis

Cited by 11 publications

References 31 publications

Synthesis, Characterization, and Bioactivities of Polysaccharide Metal Complexes: A Review

Synthesis, Characterization, and Bioactivities of Polysaccharide Metal Complexes: A Review

Target-Responsive Smart Nanomaterials via a Au–S Binding Encapsulation Strategy for Electrochemical/Colorimetric Dual-Mode Paper-Based Analytical Devices

A photocrosslinked methacrylated carboxymethyl chitosan/oxidized locust bean gum double network hydrogel for cartilage repair

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