Synthesis of Carbon Dots Originated from Hydroxypropylmethyl Cellulose for Sensing Ciprofloxacin

Wang, Shanshan; Wang, Yingyi; Yang, Kun; Zhong, Yan; Yang, Xiaoming; Chen, Zhangbao

doi:10.2116/analsci.33.1129

Cited by 15 publications

(4 citation statements)

References 34 publications

(33 reference statements)

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“…Besides their application for bio-imaging and therapy, CDs have other applications as biosensors. It was demonstrated that CDs from hydroxypropylmethyl cellulose could be used as sensors for ciprofloxacin detection 20 . A highly sensitive and selective molecularly imprinted polymer-based CDs (MIP@CDs) was prepared for the detection of acetyl cholinesterase (AChE), an essential enzyme in the diagnosis of Alzheimer's disease (AD) 21 .…”

Section: Introductionmentioning

confidence: 99%

A Perspective on Using Organic Molecules Composing Carbon Dots for Cancer Treatment

Ahmad¹,

Aung²,

Widati³

et al. 2023

Nanotheranostics

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Fluorescent Carbon dots (CDs) derived from biologically active sources have shown enhanced activities compared to their precursors. With their prominent potentiality, these small-sized (<10nm) nanomaterials could be easily synthesized from organic sources either by bottom-up or green approach. Their sources could influence the functional groups present on the CDs surfaces. A crude source of organic molecules has been used to develop fluorescent CDs. In addition, pure organic molecules were also valuable in developing practical CDs. Physiologically responsive interaction of CDs with various cellular receptors is possible due to the robust functionalization on their surface. In this review, we studied various literatures from the past ten years that reported the potential application of carbon dots as alternatives in cancer chemotherapy. The selective cytotoxic nature of some of the CDs towards cancer cell lines suggests the role of surface functional groups towards selective interaction, which results in over-expressed proteins characteristic of cancer cell lines. It could be inferred that cheaply sourced CDs could selectively bind to overexpressed proteins in cancer cells with the ultimate effect of cell death induced by apoptosis. In most cases, CDs-induced apoptosis directly or indirectly follows the mitochondrial pathway. Therefore, these nanosized CDs could serve as alternatives to the current kinds of cancer treatments that are expensive and have numerous side effects.

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Section: Introductionmentioning

confidence: 99%

A Perspective on Using Organic Molecules Composing Carbon Dots for Cancer Treatment

Ahmad¹,

Aung²,

Widati³

et al. 2023

Nanotheranostics

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“…The current methods for detection of CIP mainly include HPLC [ 14 , 15 ], LC-MS/MS [ 16 , 17 , 18 ], microbiological assay [ 19 , 20 ], fluorescence spectroscopy [ 21 , 22 , 23 ], electrochemical methods [ 24 , 25 , 26 ], immunoassay [ 27 ], and optical fiber sensor [ 28 ]. Although these methods have a good effect on the CIP response, these methods also exhibit some disadvantages that cannot be avoided, such as requiring large and cumbersome instruments, professional technicians, high cost and long analysis time, and thus their inability to meet the requirements of actual sample field testing and environmental urgent concerns.…”

Section: Introductionmentioning

confidence: 99%

A Ratiometric Fiber Optic Sensor Based on CdTe QDs Functionalized with Glutathione and Mercaptopropionic Acid for On-Site Monitoring of Antibiotic Ciprofloxacin in Aquaculture Water

Yuan

et al. 2022

Nanomaterials

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A ratiometric fluorescence fiber-optical sensor system (RFFS) merging a Y-type optical fiber spectrometer and CdTe QDs composite functionalized with glutathione and mercaptopropionic acid (GMPA@CdTe-QDs) for highly selective and on-site detection of ciprofloxacin (CIP) in environmental water samples was designed. Our preliminary results suggested that the red fluorescence of the synthesized GMPA@CdTe-QDs was effectively quenched by CIP. Based on this, the RFFS/GMPA@CdTe-QDs system was successfully fabricated and used for highly selective and rapid detection of CIP on site in the concentration range from 0 to 45 μM with the detection limit of 0.90 μM. The established method exhibited good interference resistance to the analogues of CIP and provided a great potential platform for real-time detection of CIP residues in environmental water. In addition, the fluorescence quenching mechanism of GMPA@CdTe-QDs by CIP was also investigated by means of temperature effect, fluorescence lifetime, ultraviolet (UV) visible absorption, and fluorescent spectra. Our results suggested clearly that the red fluorescence of GMPA@CdTe-QDs was quenched by CIP via the photoinduced electron-transfer (PET) mode.

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“…Carbon dots (CDs) are suitable alternatives for constructing uorescent probes ascribing to its exceptional features, such as superb optical qualities (Wang et al 2017) (Ramezani et al 2018), water solubility, high chemical stability, and great biocompatibility (Gao et al 2018) (Liu et al 2019). There are widely employed in various elds such as medication administration, metal ion sensing, biological imaging (Atchudan et al 2019), biosensors (Anh et al 2017), as well as in other domains (Zong et al 2014).…”

Section: Introductionmentioning

confidence: 99%

Determination of ciprofloxacin using the Ziziphus mauritania derived fluorescent carbon dots based optical sensor

Chaudhry

Verma

Yadav

et al. 2022

Preprint

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The rapid determination and sensitive monitoring of antibiotics residues are critical challenges and highly essential for the protection of human and environment. Hence, in the present work, facile green synthesis of fluorescent carbon quantum dots (CDs) has been done using one step hydrothermal treatment of fruit exact of Ziziphus mauritiana for the first time, acting as natural source of carbon for optical determination of ciprofloxacin (CIP). These prepared CDs was used to selectively detect CIP, exhibiting high quantum yield of 30% at excitation wavelength of 340 nm. After the optimal parameters, the sensor gave the linear detection range from 20 to 100 µM along with limit of detection of 9.20 µM. The current work depicts the potential to effectively and rapidly determine other forthcoming environmental pollutants.

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Synthesis of Carbon Dots Originated from Hydroxypropylmethyl Cellulose for Sensing Ciprofloxacin

Cited by 15 publications

References 34 publications

A Perspective on Using Organic Molecules Composing Carbon Dots for Cancer Treatment

A Perspective on Using Organic Molecules Composing Carbon Dots for Cancer Treatment

A Ratiometric Fiber Optic Sensor Based on CdTe QDs Functionalized with Glutathione and Mercaptopropionic Acid for On-Site Monitoring of Antibiotic Ciprofloxacin in Aquaculture Water

Determination of ciprofloxacin using the Ziziphus mauritania derived fluorescent carbon dots based optical sensor

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