Synthesis of carbon dots from Hypocrella bambusae for bimodel fluorescence/photoacoustic imaging-guided synergistic photodynamic/photothermal therapy of cancer

Jia, Qingyan; Zheng, Xiuli; Ge, Jiechao; Liu, Weimin; Ren, Haohui; Chen, Shiqing; Wen, Yongmei; Zhang, Hongyan; Wu, Jiasheng; Wang, Pengfei

doi:10.1016/j.jcis.2018.05.005

Cited by 119 publications

(93 citation statements)

References 79 publications

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“…Using the same mouse model, Jia and colleagues have described an innovative bimodal FL-PA imaging approach to guide synergistic PDT-PTT of cancer [83], employing the Hypocrella bambusae (HB) biomaterial as the precursor for the preparation of CNDs-based phototheranostic agents. HB-CNDs offer several advantages including a relatively simple and cheap synthetic procedure, adequate photostability, good water solubility, broad absorption, red-light emission spectra, and excellent biocompatibility.…”

Section: Biomedical Pai Applications Based On Exogenous Optical Comentioning

confidence: 99%

State-of-the-Art Preclinical Photoacoustic Imaging in Oncology: Recent Advances in Cancer Theranostics

Gargiulo

Albanese

Mancini

2019

Contrast Media & Molecular Imaging

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The optical imaging plays an increasing role in preclinical studies, particularly in cancer biology. The combined ultrasound and optical imaging, named photoacoustic imaging (PAI), is an emerging hybrid technique for real-time molecular imaging in preclinical research and recently expanding into clinical setting. PAI can be performed using endogenous contrast, particularly from oxygenated and deoxygenated hemoglobin and melanin, or exogenous contrast agents, sometimes targeted for specific biomarkers, providing comprehensive morphofunctional and molecular information on tumor microenvironment. Overall, PAI has revealed notable opportunities to improve knowledge on tumor pathophysiology and on the biological mechanisms underlying therapy. The aim of this review is to introduce the principles of PAI and to provide a brief overview of current PAI applications in preclinical research, highlighting also on recent advances in clinical translation for cancer diagnosis, staging, and therapy.

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Section: Biomedical Pai Applications Based On Exogenous Optical Comentioning

confidence: 99%

State-of-the-Art Preclinical Photoacoustic Imaging in Oncology: Recent Advances in Cancer Theranostics

Gargiulo

Albanese

Mancini

2019

Contrast Media & Molecular Imaging

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“…Biomass usually contains heteroatoms, such as N and S, which is a good choice to prepare heteroatom‐doped CDs, such as spinach, soy milk, honey, and cabbage . In our group, we used Hypocrellabambusae as precursors to prepare hydrophilic CDs for bimodal fluorescence (FL)/photoacoustic imaging‐guided synergistic PDT/PTT . Chang et al.…”

Section: Introductionmentioning

confidence: 99%

“…[21] In our group, we used Hypocrellabambusae as precursors to prepare hydrophilic CDs for bimodalf luorescence (FL)/photoacoustic imaging-guided synergistic PDT/PTT. [22] Chang et al used fresh ginger juice as carbon source to prepare CDs, which exhibited selectivity and high inhibitory effects on human hepatocellular carcinomac ells. [23] Liang et al prepared naturalb iomass CDs from lychee exocarp,t hen loaded ap hotosensitizer andt ransferrin on the surfaces of CDs for image-guided PDT of cancerc ells.…”

Section: Introductionmentioning

confidence: 99%

Pheophytin Derived Near‐Infrared‐Light Responsive Carbon Dot Assembly as a New Phototheranotic Agent for Bioimaging and Photodynamic Therapy

Wen

Jia

Nan

et al. 2019

Chemistry An Asian Journal

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Carbon dots (CDs), a kind of phototheranostic agent with the capability of simultaneous bioimaging and phototherapy [i.e., photodynamic therapy (PDT) or photothermal therapy (PTT)], have received considerable attention because of their remarkable properties, including flexibility for surface modification, high biocompatibility, low toxicity and photo‐induced activity for malignant tumor cells. Among numerous carbon sources, it has been found that natural biomass are good candidates for the preparation of CD phototheranostic agents. In this study, pheophytin, a type of Mg‐free chlorophyll derivative and also a natural product with low toxicity, was used as a raw carbon source for the synthesis of CDs by using a microwave method. The obtained hydrophobic CDs exhibited a maximum near‐infrared (NIR) emission peak at approximately 680 nm, and high singlet oxygen (1O2) generation with a quantum yield of 0.62. The self‐assembled CDs from the as‐prepared CDs with DSPE‐mPEG2000 retained efficient 1O2 generation. The obtained carbon dot assembly was not only an efficient fluorescence (FL) imaging agent but also a smart PDT agent. Our studies indicated that the obtained hydrophilic CD assembly holds great potential as a new phototheranostic agent for cancer therapy. This work provides a new route for synthesis of CDs and proposes a readily available candidate for tumor treatment.

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“…Next, the green fluorescent indicator 2,7-dichlorofluorescein diacetate (DCF-DA) was utilized to prove the 1 O 2 generation of DAHB@CaP NRs in HeLa cells. [15] When the HeLa cells were treated with DAHB@CaP NRs or DCF-DA alone, no luminescence was observed upon 671 nm laser irradiation for 3 min ( Figure 3F). However, the HeLa cells exhibited strong green fluorescence after co-incubation with DAHB@CaP NRs and DCF-DA, followed by irradiation with a 671 nm laser, thereby demonstrating the efficient 1 O 2 generation of DAHB@CaP NRs upon NIR light irradiation.…”

Section: Hypocrellin Derivative-loaded Calcium Phosphate Nanorods As mentioning

confidence: 99%

Hypocrellin Derivative‐Loaded Calcium Phosphate Nanorods as NIR Light‐Triggered Phototheranostic Agents with Enhanced Tumor Accumulation for Cancer Therapy

et al. 2019

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Dopamine modified hypocrellin B (DAHB) derivative‐loaded calcium phosphate nanorods (DAHB@CaP NRs) were prepared as a novel phototheranostic agent for effective tumor imaging and therapy. DAHB@CaP NRs were obtained through microwave treatment using DAHB, CaCl2, NH3⋅H2O, and H3PO4 as precursors. The DAHB@CaP NRs possessed the following advantages: 1) efficient absorption in the near‐infrared (NIR) region from 650 nm to 800 nm; 2) maximum NIR emission at approximately 735 nm; 3) enhanced cellular uptake efficiency in vitro and in vivo; and 4) efficient inhibition of tumor growth and low biotoxicity. These properties indicate the high capability of DAHB@CaP NRs for NIR fluorescence (FL) imaging‐guided photodynamic therapy of cancer, thus offering promising new prospects for clinical applications.

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Synthesis of carbon dots from Hypocrella bambusae for bimodel fluorescence/photoacoustic imaging-guided synergistic photodynamic/photothermal therapy of cancer

Cited by 119 publications

References 79 publications

State-of-the-Art Preclinical Photoacoustic Imaging in Oncology: Recent Advances in Cancer Theranostics

State-of-the-Art Preclinical Photoacoustic Imaging in Oncology: Recent Advances in Cancer Theranostics

Pheophytin Derived Near‐Infrared‐Light Responsive Carbon Dot Assembly as a New Phototheranotic Agent for Bioimaging and Photodynamic Therapy

Hypocrellin Derivative‐Loaded Calcium Phosphate Nanorods as NIR Light‐Triggered Phototheranostic Agents with Enhanced Tumor Accumulation for Cancer Therapy

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