Synthesis of carbon‐14 labeled capsaicin

Bodine, Richard S.; Chien, Ping-Lu

doi:10.1002/jlcr.2580211005

Cited by 3 publications

(1 citation statement)

References 3 publications

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“…To investigate this pathway, methods for the synthesis of isotopically labelled precursors are required. The total synthesis of a carbon‐14 labelled version of capsaicin, labelled in the benzylic position, was published by Bodine and Chien5. An improved version of this synthesis has subsequently been reported 6.…”

Section: Introductionmentioning

confidence: 99%

Synthesis and elucidation of deuterated vanillylamine hydrochloride and capsaicin

Kim

Park

Jung

et al. 2009

Labelled Comp Radiopharmac

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Capsaicin is the major pungent component of hot peppers, which belong to the plant genus Capsicum. Although the biosynthesis of capsaicin is known to involve the condensation of vanillylamine and 8-methylnonenoic acid by capsaicin synthase, the mechanism of biosynthesis is still not fully understood. In this study, deuterium labelled versions of capsaicin and the precursor vanillylamine were synthesized in order to investigate the biosynthesis of capsaicin in hot peppers.

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Section: Introductionmentioning

confidence: 99%

Synthesis and elucidation of deuterated vanillylamine hydrochloride and capsaicin

Kim

Park

Jung

et al. 2009

Labelled Comp Radiopharmac

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Syntheses and uses of isotopically labelled hydroxyl compounds and ethers

Zieliński

Kańska

1993

PATAI'S Chemistry of Functional Groups

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12th Workshop of the Central European Division e.V. of the International Isotope Society

Snieckus

Geach²,

Randall³

et al. 2004

Labelled Comp Radiopharmac

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V Snieckus [Queen's University, Canada]—The Directed Ortho Metalation—Cross Coupling Symbiosis in Aromatic Synthesis. N Geach, GP Randall, CJ Winfield [Scynexis, UK]—Isotopically Labelled 4‐Formylimidazole. A Studer [Marburg University, Germany]—New Concepts in Tin‐Free Radical Chemistry. AC Spivey, C Noban [Imperial College London, UK]. T Jones [Sheffield University, UK], GJ Ellames, A Kohler [Sanofi‐Synthélabo, UK], H Wadsworth [Amersham Biosciences, UK]—Opportunities for Isotope Labelling via Solid Phase Synthesis with Organogermanium Linkers. J Rieke‐Zapp [Aventis Pharma, Germany]—Optimization of Reaction Conditions on mg‐Scale by Use of Screening Devices. S Stone‐Elander [Karolinska Institute, Sweden]—Rerouting Radiochemistry with Microwaves. J Goehl, B Perry, D Leuck, J Windels, M Marx [EaglePicher Pharmaceutical, USA]—GMP and Radiolabelled Syntheses of Capsaicin. J Krüger, B Manmontri, G Fels [Paderborn University, Germany]—H/D‐Exchange in Aromatic Systems Using Transition Metal Catalysis. F Wüst, T Kniess, R Bergmann [Research Centre Rossendorf, Germany]—Synthesis of a 11C‐Labelled Nonsteroidal Glucocorticoid Receptor Ligand as Potential Radiotracer for Imaging Brain Glucocorticoid Receptors with Positron Emission Tomography (PET). P Mäding, F Füchtner [Research Centre Rossendorf, Germany], CS Hilger [Schering AG, Germany]. M Halks‐Miller, R Horuk [Berlix Biosciences, USA]—18F‐Labelling of a Potent Nonpeptide CCR1 Antagonist for the Diagnosis of the Alzheimer's Disease. L Matei, C Postolache, V Fugaru, E Condac, A Dinischiotu, M Costache [Bukarest University, Romania]—Use of [1,2‐3H] Testosterone in 5α‐ Reductase Enzymatic Activity Dosing in Dermal Fibroblast Cultures from Polycystic Ovarian Patients. L Matei, C Postolache, V Fugaru [Bukarest University, Romania]—Synthesis and Stability Studies of Acyclovir Labelled with Tritium. J Atzrodt, V Derdau [Aventis Pharma, Germany]—Studies on Directed Ortho‐Metalation (DoM) as Convenient Tool for the Synthesis of Labeled Compounds.

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Synthesis of carbon‐14 labeled capsaicin

Abstract: SUMMARYThe synthesis and purification of carbon-14 labeled capsaicin are described.

Cited by 3 publications

References 3 publications

Synthesis and elucidation of deuterated vanillylamine hydrochloride and capsaicin

Synthesis and elucidation of deuterated vanillylamine hydrochloride and capsaicin

Syntheses and uses of isotopically labelled hydroxyl compounds and ethers

12th Workshop of the Central European Division e.V. of the International Isotope Society

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