Synthesis of C14- and C16-carbon chain containing mannitol diester and diether based non-ionic amphiphiles and studies of their Langmuir monolayer films at the air/water interface

Synthesis of d‐glucitolbased Gemini amphiphilic nanotransporters

“…16 Carbohydrate-based transport systems, also known as glycotargets have recently received much attention as drug delivery systems. [17][18][19][20][21] The preparation of amphiphilic nanocarrier containing carbohydrate scaffolds like sorbitan, 22,23 mannitol, 24 glycosides, 25 glycoproteins, 26 polysaccharides 27 has been widely documented. 28 Ghosh et al have prepared C 14 and C 16 alkyl chains comprising mannitol diether and diester-based nonionic amphiphiles and studied their air/water interface.…”

“…28 Ghosh et al have prepared C 14 and C 16 alkyl chains comprising mannitol diether and diester-based nonionic amphiphiles and studied their air/water interface. 20 Our group has studied the self-assembly and transport behavior of polyglycerol dendron and carbohydrate-based amphiphiles for drug delivery applications. 29,30 Furthermore a series of nonionic D-glucitolbased amphiphiles with phenyl and naphthyl hydrophobic units and triglycerol, glycerol, and mPEG azide hydrophilic moieties were developed to explore their transport behavior.…”

“…Carbohydrate–protein interactions are intricate in many standard and pathological processes involving viral and bacterial infection, inflammation, cell adhesion, and cancer metastatic 16 . Carbohydrate‐based transport systems, also known as glycotargets have recently received much attention as drug delivery systems 17–21 . The preparation of amphiphilic nanocarrier containing carbohydrate scaffolds like sorbitan, 22,23 mannitol, 24 glycosides, 25 glycoproteins, 26 polysaccharides 27 has been widely documented 28 .…”

Self-assembly of carbohydrate-based small amphiphiles and their applications in pathogen inhibition and drug delivery: a review

“…However, certain advantages associated with carbohydrate-based amphiphilic architectures such as their pH-independent self-assembling behaviour, multiple functionalities, biocompatibility and mildness to the skin, make them potential candidates for biomedical applications. 23 In the present context of the review, herein we have summarized the literature reports published in recent years on different types of carbohydrate-based small non-ionic amphiphiles along with the size and shape of their self-assembled nanostructures formed in an aqueous environment, and their applications in pathogen inhibition and drug delivery. The information is described in two sections, the first one discusses lectin recognition and pathogen inhibition potential of self-assembled nanostructures formed by small carbohydrate-based amphiphiles, while the content of the second section explores carbohydrate-based nanostructures for drug delivery applications.…”

Nonionic Dendritic and Carbohydrate Based Amphiphiles: Self‐Assembly and Transport Behavior

“…through multivalent interactions with respective receptors (i.e., lectins) . Nonionic amphiphiles bearing carbohydrate head groups have received special interest in the areas of food, pharmaceuticals, cosmetics, and detergents due to their biodegradability, biocompatibility, and mildness to skin . Percec et al have synthesized a series of amphiphilic Janus glycodendrimers with the monosaccharides d ‐mannose and d ‐galactose and the disaccharide d ‐lactose in their hydrophilic part.…”