Synthesis of C-phosphorylated acetamidines containing CH-acidic methylene group

Synthesis of Tetrazole-Containing C-Phosphonoacetamidines

“…Hence, there is a need to develop facile and efficient approaches towards the synthesis of such building blocks. Very few examples have been described of preparations of phosphorussubstituted amidines, such as C-phosphoryl- [19][20][21][22] and Nphosphorylamidines. [23][24][25][26] Further developing our previous studies on the chemistry of functionalized aminophosphorus derivatives, [27][28][29] herein we report the regioselective synthesis of novel tetrazolyl-containing C-phosphonоaсetamidines 3a-j from phosphorylated aldoketenimines 1a,b.…”