Synthesis of boronated derivatives of chlorin e6 with amide bond

Synthesis of potential antitumor agents, dimeric and trimeric chlorins, from methylpheophorbide a

“…8,9 The hydr oxy derivative of chlorin е 6 (11) was synthesized by the reaction of aminochlorin 3 with succinic anhydride as described earlier. 12 The spectral characteristics of compounds 1-7, 11, and 12 are analogous to those presented in the literature. Methylpheo phorbide d (7) was obtained by the known procedure.…”

“…Methyl pheophorbide а (1) was obtained according to the procedure described earlier. 7 15,17 Dimethyl chlorin e 6 13 N (2 amino ethyl)amide (3), 15,17 dimethyl chlorin e 6 13 N (6 amino hexyl)amide (4), and 15 methyl chlorin e 6 13,17 N,N´ (2 aminoethyl)diamide (10) were synthesized by the treatment of methylpheophorbide а with ethylenediamine and hexamethyl enediamine using our earlier developed procedures 8-10 ; pheo phorbide а (5), methylpyropheophorbide а (12), and pyro pheophorbide а (6) were synthesized as described in the litera ture. 11 15,17 Dimethyl chlorin e 6 13 N (2 hydroxyethyl)amide (2) was synthesized by the action of ethanolamine on methyl phephorbide а using the procedure described earlier.…”

Conjugates of Chlorophyll a Derivatives with Betulin

“…Метилфеофорбид а 1, феофорбид а 5 и пирофеофорбид а 7 были получены согласно литературным методикам. [7,8] Карбокси-хлорин 3 был получен по методике [9] . При описании спектров ЯМР номера атомов углерода бетулинового фрагмента обозначаются знаком «'».…”