Synthesis of bodinieric acids A and B, both C-18 and C-19-functionalized abietane diterpenoids: DFT study of the key aldol reaction

Abstract

The first synthesis of C-18- and C-19-bifunctionalized abietane diterpenoids, bodinieric (or callicapoic) acids, via an aldol reaction has been developed.

Total synthesis of naturally occurring abietane diterpenoids via a late-stage Fe(iii)-bTAML catalysed Csp3–H functionalization

“…To this end, research in our group along with that in other synthetic groups ( e.g. , Corey, 15 Alvarez-Manzaneda, 16 Matsumoto, 17 Tada, 18 Burnell, 19 Gonzalez, 20 ) focused on the development of new synthetic strategies to access abietane-type diterpenoids. Synthetic challenges include stereoselective installation of three adjacent carbon stereocenters and formation of the polyoxygenated moiety.…”