Synthesis of bis(trifluoromethyl)pyrimido[4,5-d]pyrimidine-2,4-diones and evaluation of their antibacterial and antifungal activities

Novel N-benzyl-2-oxo-1,2-dihydrofuro [3,4-d]pyrimidine-3(4H)-carboxamide as anticancer agent: Synthesis, drug-likeness, ADMET profile, DFT and molecular modelling against EGFR target

“…Pyrimidine, an important nitrogen-containing aromatic heterocyclic compound, is found in the structure of DNA and RNA, which carry the necessary information for life. Many different pyrimidine compounds have been first designed, and then synthesized, and it has been seen that they have quite a lot of biological effects such as anti-proliferative [ 1 ], antiviral [ 2 ], antitumor [ 3 ], anti-inflammatory [ 4 ], antibacterial [ 5 ], antifungal [ 6 ], anti-β-glucuronidase [ 7 ]. Also, its anti-Alzheimer [ 8 ] and anti-tuberculosis [ 9 ] effects have been identified.…”

Utility of 6-Aminouracils for Building Substituted and Heteroannulated Pyrimidines: A Comprehensive Review

“…1,2 Uracil (pyrimidine-2,4(1H,3H)-dione) is a common and naturally occurring pyrimidine derivative and represents one of the four nucleobases in the nucleic acid (RNA). 3 Numerous derivatives of uracil have incredible utility in biology and in medicinal chemistry 4 such as anticancer, 5 antitumor, 6 antineoplastic, 7 antiprotozoal, 8 anti-HIV, 9 anti-HCMV, 10 antitubercular, 11 antiviral, 12 antifungal, 13 antibacterial, 14 insecticidal, 15 herbicidal, 16 and antimicrobial activities. 17 Azo-uracils have been used as hypotonic drugs.…”

Synthesis of Some Novel Thiazolo[3,2‐a]pyrimidine and Pyrimido[2,1‐b][1,3]thiazine Derivatives and their Antimicrobial Evaluation

“…They exhibited anticancer [1][2][3][4][5], antioxidant [6][7][8], antifungal [9,10], and antibacterial activities [11][12][13][14]. They exhibited anticancer [1][2][3][4][5], antioxidant [6][7][8], antifungal [9,10], and antibacterial activities [11][12][13][14].…”