Synthesis of biologically active phosphorus heterocycles via cyclization reactions of Lawesson's reagent

Studies on Phosphoroheterocycle Chemistry II: A Simple and New Route to 1, 3, 2-Diazaphospholidine-4-thione 2-sulfide Derivatives

“…[6][7][8] More recently, Lawesson's reagent has been found to be efficient in such synthesis when treated with corresponding substituted glycinamides. [9][10][11] It was further shown that some of 1,3,2diazaphospholidine-4-thione 2-sulfides exhibited highly selective herbicidal activity. 10,11 This has led us to exploit a new methodology for the rapid synthesis of such phosphoroheterocycle in high yields.…”

“…[9][10][11] It was further shown that some of 1,3,2diazaphospholidine-4-thione 2-sulfides exhibited highly selective herbicidal activity. 10,11 This has led us to exploit a new methodology for the rapid synthesis of such phosphoroheterocycle in high yields. We report here a new and simple procedure for the synthesis of 1,3,2-diazaphospholidine-4-thione 2-sulfide derivatives, as shown in Scheme 1.…”