Synthesis of bioinspired based hydrogel composite from hyaluronic acid/polyacrylic acid and lignin as an adhesive for medical technology

Mechanosensing and mechanotransduction pathways between the Extracellular Matrix (ECM) and cells form the essential crosstalk that regulates cell homeostasis, tissue development, morphology, maintenance, and function. Understanding these mechanisms involves creating an appropriate cell support that elicits signals to guide cellular functions. In this context, polymers can serve as ideal molecules for producing biomaterials designed to mimic the characteristics of the ECM, thereby triggering responsive mechanisms that closely resemble those induced by a natural physiological system. The generated specific stimuli depend on the different natural or synthetic origins of the polymers, the chemical composition, the assembly structure, and the physical and surface properties of biomaterials. This review discusses the most widely used polymers and their customization to develop biomaterials with tailored properties. It examines how the characteristics of biomaterials-based polymers can be harnessed to replicate the functions of biological cells, making them suitable for biomedical and biotechnological applications.

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Biomaterials-Based Hydrogels for Therapeutic Applications

Chelu,

Magdalena Musuc

2024

Biomaterials in Microencapsulation

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Conventional therapeutic models based on the premise of a universal solution are facing a decrease in efficiency, emphasized by the large number of patients who show resistance or who do not respond positively to classic treatments. This perspective highlights the urgency for more precise approaches based on personalized treatments that are adaptable to the specific complexities and unique challenges faced by each patient. Hydrogels are biocompatible and biodegradable systems for well-controlled and targeted administration of therapeutic agents, being formed by 3D reticulated networks of water-soluble polymeric biomaterials, of natural, synthetic, or hybrid origin, with specific intrinsic and extrinsic properties. Due to the easily adjustable porous structure, hydrogels allow the encapsulation of macromolecular drugs, proteins, small molecules, cells, hormones, or growth factors in the gel matrix and their subsequent controlled release. The biomaterials used, the crosslinking methods, the design, and the functionalization strategies in obtaining hydrogels with improved properties are presented. The different possibilities of application are described transdermally, as dressing materials, oral, ocular, spray-able, or injectable, up to the intracellular level. This chapter extensively investigates the advances and unique advantages of hydrogels that enable effective, noninvasive, personalized treatments and provide greater patient comfort for a wide range of applications.

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Synthesis of bioinspired based hydrogel composite from hyaluronic acid/polyacrylic acid and lignin as an adhesive for medical technology

Cited by 3 publications

References 35 publications

On the design of lignin reinforced acrylic acid/hyaluronic acid adhesive hydrogels with conductive PEDOT:HA nanoparticles

On the design of lignin reinforced acrylic acid/hyaluronic acid adhesive hydrogels with conductive PEDOT:HA nanoparticles

Biomaterials Mimicking Mechanobiology: A Specific Design for a Specific Biological Application

Biomaterials-Based Hydrogels for Therapeutic Applications

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