Synthesis of biogenic cadmium sulfide nanoparticles (MR03-CdSNPs) using marine Streptomyces kunmingensis - MR03 for in-vitro biological determinations and in silico analysis on biofilm virulence proteins: A novel approach

Elumalai, Lokesh; Palaniyandi, Sankarganesh; Anbazhagan, Ganesh Kumar; Mohanam, Nithyalakshmi; Munusamy, Santhakumar; G.K, Sri Ragavi; Pudukadu Munusamy, Ayyasamy; Chinnasamy, Muthusamy; Ramasamy, Balagurunathan

doi:10.1016/j.envres.2023.116698

Cited by 3 publications

(1 citation statement)

References 70 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…We used Schrodinger 2023-3 software to prepare and optimize the structure of the protein, using the OPLS_2005 force field to remove heteroatoms (Schrodinger, LLC, New York, NY, USA). The binding site of the protein structure was identified using SitMap (Sitemap, Version 4.3), available in Maestro, and some other physical characteristics such as hydrogen bonding, hydrophobicity, size, and linking point [15]. A grid created at 12 Å × 12 Å × 12 Å was virtually screened and run in VSW (virtual screening workflow module).…”

Section: Prediction Of Ligand and Protein Interactionmentioning

confidence: 99%

Patchouli Alcohol: A Potent Tyrosinase Inhibitor Derived from Patchouli Essential Oil with Potential in the Development of a Skin-Lightening Agent

Kumar,

Vani,

Chinnasamy

et al. 2024

Cosmetics

Self Cite

View full text Add to dashboard Cite

The inhibitory effects of Pogostemon cablin essential oil (patchouli essential oil, PEO) and its primary bioactive compound, patchouli alcohol (PA), on tyrosinase and melanin were investigated in vitro and ex vivo. Treatment with PEO and PA significantly, as well as dose-dependently, reduced forskolin (FRK)-induced melanin biosynthesis, cellular tyrosinase activity, and tyrosinase (TYR) protein expression. However, the transcriptional levels of TYR and tyrosinase-related proteins (TRP-1 and TRP-2) remained unaffected. These results suggest that PEO and PA may directly interrupt tyrosinase enzyme activity, leading to a reduction in melanin biosynthesis. Further experiments supported this notion, revealing that both PEO and PA significantly and dose-dependently inhibited mushroom tyrosinase activity in both the monophenolase and diphenolase phases. Additionally, an in silico molecular docking analysis was performed, utilizing a homology model of human tyrosinase. In conclusion, these findings strongly suggest that patchouli essential oil and its primary bioactive component, patchouli alcohol, hold promise as potential treatments for hyperpigmentary skin conditions and in the development of cosmetic products designed to lighten the skin.

show abstract

Section: Prediction Of Ligand and Protein Interactionmentioning

confidence: 99%

Patchouli Alcohol: A Potent Tyrosinase Inhibitor Derived from Patchouli Essential Oil with Potential in the Development of a Skin-Lightening Agent

Kumar,

Vani,

Chinnasamy

et al. 2024

Cosmetics

Self Cite

View full text Add to dashboard Cite

show abstract

Bioactive compound from marine seagrass Streptomyces argenteolus TMA13: combatting fish pathogens with time-kill kinetics and live-dead cell imaging

Elumalai,

Nagarajan,

Anbalmani

et al. 2024

Braz J Microbiol

View full text Add to dashboard Cite

Bacterial synthesis of metal nanoparticles as antimicrobials

Arora,

Lashani,

Turner

2024

Microbial Biotechnology

View full text Add to dashboard Cite

Nanoscience, a pivotal field spanning multiple industries, including healthcare, focuses on nanomaterials characterized by their dimensions. These materials are synthesized through conventional chemical and physical methods, often involving costly and energy‐intensive processes. Alternatively, biogenic synthesis using bacteria, fungi, or plant extracts offers a potentially sustainable and non‐toxic approach for producing metal‐based nanoparticles (NP). This eco‐friendly synthesis approach not only reduces environmental impact but also enhances features of NP production due to the unique biochemistry of the biological systems. Recent advancements have shown that along with chemically synthesized NPs, biogenic NPs possess significant antimicrobial properties. The inherent biochemistry of bacteria enables the efficient conversion of metal salts into NPs through reduction processes, which are further stabilized by biomolecular capping layers that improve biocompatibility and functional properties. This mini review explores the use of bacteria to produce NPs with antimicrobial activities. Microbial technologies to produce NP antimicrobials have considerable potential to help address the antimicrobial resistance crisis, thus addressing critical health issues aligned with the United Nations Sustainability Goal #3 of good health and well‐being.

show abstract

Synthesis of biogenic cadmium sulfide nanoparticles (MR03-CdSNPs) using marine Streptomyces kunmingensis - MR03 for in-vitro biological determinations and in silico analysis on biofilm virulence proteins: A novel approach

Cited by 3 publications

References 70 publications

Patchouli Alcohol: A Potent Tyrosinase Inhibitor Derived from Patchouli Essential Oil with Potential in the Development of a Skin-Lightening Agent

Patchouli Alcohol: A Potent Tyrosinase Inhibitor Derived from Patchouli Essential Oil with Potential in the Development of a Skin-Lightening Agent

Bioactive compound from marine seagrass Streptomyces argenteolus TMA13: combatting fish pathogens with time-kill kinetics and live-dead cell imaging

Bacterial synthesis of metal nanoparticles as antimicrobials

Contact Info

Product

Resources

About