Synthesis of biocompatible nanocomposite hydrogels as a local drug delivery system

Bakó, József; Szepesi, Márta; Veres, Adrienn J.; Cserháti, Csaba; Borbély, Zsuzsa; Hegedűs, Csaba; Borbély, János

doi:10.1007/s00396-007-1793-7

Cited by 20 publications

(14 citation statements)

References 28 publications

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“…Nanometer‐scale integration of both organic and inorganic components offers controllable mechanical strength and swelling,11–13 stimuli‐responsive behaviour associated with magnetic14, optical,15 or electric fields,16, 17 and changes in temperature 18, 19. In addition, nanocomposite polymer hydrogels with high biocompatibility have been exploited in wound dressings,20 cell cultivation and release,21, 22 tissue engineering,23 and bone remediation,24 and used as host matrices for the immobilization of anti‐bactericides,25, 26 proteins,27 and drug molecules 28. Typically, release of hydrophilic drug molecules entrapped within conventional hydrogels29–31 or nanocomposite polymer hydrogels32 is complete within 12–24 hours, and as a consequence, long‐term sustainable release, as well as multi‐modal kinetics of delivery, are difficult to achieve.…”

Section: Introductionmentioning

confidence: 99%

Guest‐Molecule‐Directed Assembly of Mesostructured Nanocomposite Polymer/Organoclay Hydrogels

Martin

Patil

Butler

et al. 2010

Adv Funct Materials

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Given the urgent need for soft materials with high functional value, hydrogels based on the integrative assembly of organic polymers and nanoscale inorganic building blocks-so-called nanocomposite polymer hydrogels-offer a generic approach to swollen hybrid networks with tuneable and synergistic properties. Here, we report a new approach to assembling nanocomposite polymer hydrogels with multiple levels of structural complexity and enhanced functionality by using nanoscale integration of mesostructured inorganic building blocks capable of sequestering and releasing drugs (ibuprofen, aspirin, naproxen) and enzymes (glucose oxidase). The viscoelastic materials are produced by noncovalent crosslinking of poly(vinylpyrrolidone) in the presence of low amounts (1-5 wt%) of an exfoliated synthetic organoclay that undergoes in situ guest-molecule-directed self-assembly. The hydrogels can be moulded into shape-persistent, free-standing objects that are stable between pH values of 4 to 11 and self-heal when damaged. Signifi cantly, the mesostructured nanocomposite polymer hydrogels, which can be reversibly dried and reconstituted in the form of highly swollen materials, exhibit sustained drug release and can be recharged and reused. The results provide important guidelines for developing new multifunctional nanocomposite polymer hydrogels based on the concerted self-assembly of inorganic building blocks with mesostructured interiors.

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Section: Introductionmentioning

confidence: 99%

Guest‐Molecule‐Directed Assembly of Mesostructured Nanocomposite Polymer/Organoclay Hydrogels

Martin

Patil

Butler

et al. 2010

Adv Funct Materials

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“…Finally, they developed nanogels by blending the NPs, monomers, and drug in an aqueous solution and then crosslinked it by photopolymerization. This integrated gel system demonstrated distinct advantages compared to simple NPs or hydrogels as a delivery system, and hence, provides the chance of flexible intra-pocket drug delivery in periodontal disease treatment [41].…”

Section: Nanogels In Periodontitismentioning

confidence: 99%

Applicability of Nanoparticles-Hydrogel Composite in Treating Periodontal Diseases and Beyond

Aminu

Toh²

2017

Asian J Pharm Clin Res

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Nanoparticles (NPs)-hydrogel composite (nanogels) have yielded a surge in the design and development of novel drug delivery systems for the treatment of many ailments, including periodontal disease. The recent innovations in nanotechnological drug carrier systems seem promising, as it provides a means to improve the bioavailability of poorly soluble drugs, formulations of controlled and targeted drug delivery systems, and drug release control based on the stimuli response, among others. Several polymeric NPs-hydrogel coformulations have been investigated during the last few years, mostly using synthetic and natural polymers. Some of the results and rewards achieved from these novel approaches are the use of bioadhesive polymers to achieve prolonged drug release, the increment of intra-pocket drug penetration, the enhancement of mechanical properties using chemical crosslinkers, and the possibility of loading multiple drugs in a unit delivery system. Furthermore, these nanotechnological advances have also shown that NPs possess great potential as drug carriers in periodontal disease treatment. The future utilization of these advantages will significantly improve dental care. The coformulation of NPs-hydrogel composite will yield additional benefits that are much greater than ordinary NPs or hydrogels in delivering of drug into the periodontal pockets. The aim of this review article is to summarize updates on the current and future nanotechnological approaches that are being investigated for the treatment of periodontitis, with particular attention to the nanogels, and to identify arenas which its exploration might lead to the development of effective intra-pocket drug delivery systems for the treatment of periodontal diseases. The review also provides brief applications of nanogels in the management of other diseases.

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“…Several kinds of antimicrobial molecules from different families have been used, such as acids, amino acids, alcohols, terpenes, peptides, proteins, polysaccharides antiseptics, metal oxides, and metal salts . Many additives have been tested to obtain the best antimicrobial activity and to create an optimal material.…”

Section: Introductionmentioning

confidence: 99%

“…The antimicrobial agent can be introduced during the process directly in the bulk with the raw material or by an immobilization on the package's surface. [6][7][8][9][10][11] Several kinds of antimicrobial molecules from different families have been used, such as acids, [12][13][14][15][16] amino acids, 11,17 alcohols, terpenes, [18][19][20] peptides, proteins, [21][22][23][24] polysaccharides 25,26 antiseptics, [27][28][29][30][31][32][33] metal oxides, and [34][35][36] metal salts. [37][38][39][40][41][42] Many additives have been tested to obtain the best antimicrobial activity and to create an optimal material.…”

Section: Introductionmentioning

confidence: 99%

Antimicrobial materials based on poly(ethylene‐co‐vinyl alcohol) and silver acetate produced by reactive extrusion

Paillot

Farhat

Becquart

et al. 2019

J of Applied Polymer Sci

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The use of silver as an antimicrobial agent has exhibited great interest in recent years. In this research, poly(ethylene‐co‐vinyl alcohol) (EVOH)–silver acetate‐based antimicrobial materials were prepared at high temperature by reactive extrusion. Silver acetates were used without pretreatment. The thermal reaction of silver acetates in the material and their effect on the thermal and mechanical properties of the polymer were investigated as a function of their concentration. The dispersed silver acetate salts within the EVOH matrix have displayed a significant thermal reaction. This reaction of metallic salts was partial when the extrusion temperature was fixed at 190 °C and completed at 230 °C. The antimicrobial agents also had significant effects on the properties of the matrix. Reductions of glass temperature and storage modulus were observed by the analyses. All the variations were dependent on both the concentration of silver acetate and the extrusion parameters. The antimicrobial activity was studied and demonstrated a promising potential to create an antimicrobial material in a one‐step solvent free extrusion method. © 2019 Wiley Periodicals, Inc. J. Appl. Polym. Sci. 2019, 136, 47799.

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Synthesis of biocompatible nanocomposite hydrogels as a local drug delivery system

Cited by 20 publications

References 28 publications

Guest‐Molecule‐Directed Assembly of Mesostructured Nanocomposite Polymer/Organoclay Hydrogels

Guest‐Molecule‐Directed Assembly of Mesostructured Nanocomposite Polymer/Organoclay Hydrogels

Applicability of Nanoparticles-Hydrogel Composite in Treating Periodontal Diseases and Beyond

Antimicrobial materials based on poly(ethylene‐co‐vinyl alcohol) and silver acetate produced by reactive extrusion

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