Synthesis of bioactive hemoglobin-based oxygen carrier nanoparticles via metal-phenolic complexation

Nadimifar, Mohammadsadegh; Jin, Weiguang; Coll-Satue, Clara; Bor, Gizem; Kempen, Paul Joseph; Moosavi-Movahedi, Ali Akbar; Hosta-Rigau, Leticia

doi:10.1016/j.bioadv.2023.213698

Cited by 2 publications

(1 citation statement)

References 53 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…The role of nanomaterials in drug delivery and disease treatment has received increased research attention due to the rapid development of nanotechnology [59,60], which provides new opportunities for developing HBOCs. Nanomaterial-related HBOCs (Nano-HBOCs) are prepared by organically conjugating of nanomaterials with hemoglobin through encapsulation, self-assembly, bioconjugation, entrapment, and attachment [61][62][63]. This approach not only closely mimics the physiological structure of natural RBCs but also offers more advantages, such as reduced the vasoactivity, improved circulation time [64][65][66], and enhanced biological safety [67] (Table 1).…”

Section: Introductionmentioning

confidence: 99%

Nanomaterial-related hemoglobin-based oxygen carriers, with emphasis on liposome and nano-capsules, for biomedical applications: current status and future perspectives

Zhu,

Wang,

Xiao

et al. 2024

J Nanobiotechnol

View full text Add to dashboard Cite

Oxygen is necessary for life and plays a key pivotal in maintaining normal physiological functions and treat of diseases. Hemoglobin-based oxygen carriers (HBOCs) have been studied and developed as a replacement for red blood cells (RBCs) in oxygen transport due to their similar oxygen-carrying capacities. However, applications of HBOCs are hindered by vasoactivity, oxidative toxicity, and a relatively short circulatory half-life. With advancements in nanotechnology, Hb encapsulation, absorption, bioconjugation, entrapment, and attachment to nanomaterials have been used to prepare nanomaterial-related HBOCs to address these challenges and pend their application in several biomedical and therapeutic contexts. This review focuses on the progress of this class of nanomaterial-related HBOCs in the fields of hemorrhagic shock, ischemic stroke, cancer, and wound healing, and speculates on future research directions. The advancements in nanomaterial-related HBOCs are expected to lead significant breakthroughs in blood substitutes, enabling their widespread use in the treatment of clinical diseases. Graphical Abstract

show abstract

Section: Introductionmentioning

confidence: 99%

Nanomaterial-related hemoglobin-based oxygen carriers, with emphasis on liposome and nano-capsules, for biomedical applications: current status and future perspectives

Zhu,

Wang,

Xiao

et al. 2024

J Nanobiotechnol

View full text Add to dashboard Cite

show abstract

Comparative Evaluation of UV-Vis Spectroscopy-Based Approaches for Hemoglobin Quantification: Method Selection and Practical Insights

Coll-Satue,

Jansman,

Hosta-Rigau

2024

Biomolecules

View full text Add to dashboard Cite

The growing demand for effective alternatives to red blood cells (RBCs) has spurred significant research into hemoglobin (Hb)-based oxygen carriers (HBOCs). Accurate characterization of HBOCs—including Hb content, encapsulation efficiency, and yield—is crucial for ensuring effective oxygen delivery, economic viability, and the prevention of adverse effects caused by free Hb. However, the choice of quantification methods for HBOCs is often driven more by tradition than by a thorough assessment of available options. This study meticulously compares various UV-vis spectroscopy-based methods for Hb quantification, focusing on their efficacy in measuring Hb extracted from bovine RBCs across different concentration levels. The findings identify the sodium lauryl sulfate Hb method as the preferred choice due to its specificity, ease of use, cost-effectiveness, and safety, particularly when compared to cyanmethemoglobin-based methods. Additionally, the study discusses the suitability of these methods for HBOC characterization, emphasizing the importance of considering carrier components and potential interferences by analyzing the absorbance spectrum before selecting a method. Overall, this study provides valuable insights into the selection of accurate and reliable Hb quantification methods, which are essential for rigorous HBOC characterization and advancements in medical research.

show abstract

Synthesis of bioactive hemoglobin-based oxygen carrier nanoparticles via metal-phenolic complexation

Cited by 2 publications

References 53 publications

Nanomaterial-related hemoglobin-based oxygen carriers, with emphasis on liposome and nano-capsules, for biomedical applications: current status and future perspectives

Nanomaterial-related hemoglobin-based oxygen carriers, with emphasis on liposome and nano-capsules, for biomedical applications: current status and future perspectives

Comparative Evaluation of UV-Vis Spectroscopy-Based Approaches for Hemoglobin Quantification: Method Selection and Practical Insights

Contact Info

Product

Resources

About