Synthesis of benzylpiperazine derivatives containing the pyrazine moiety with potential activity against M. tuberculosis/Síntese de derivados da benzilpiperazina contendo a fracção pirazina com potencial actividade contra a M. tuberculosis

Abstract

Tuberculosis (TB), remains a global health challenge, despite the many efforts and recent advances in medicine and pharmacology. The World Health Organization estimates that 1.5 million people worldwide died due to TB infection in 2018. In this context, the search for novel molecules that can offer higher potency, shorter treatment times, and fewer side effects is urgent. This work describes the synthesis of eight new benzylpiperazines containing the pyrazine moiety, with potential activity against TB. The structures were rationally planned using the molecular hybridization technique, from the drug pyrazinamide and the benzylpiperazine core. All proposed substances were obtained from a simple and reproductible synthetic process, in low yields.