Synthesis of Benzyl Thioethers by C−S Coupling of Benzylic Trimethylammonium Salts and Sulfonyl Chlorides
Xiujuan Ma,
Haoyu Jin,
Min Zeng
et al.
Abstract:A facile and efficient method to synthesize thioethers from sulfonyl chlorides and benzylic trimethylammonium salts is presented. This protocol provides a simple and direct approach to realize the reductive coupling reaction of readily available sulfonyl chlorides with benzyl ammonium salts in the presence of triphenylphosphine along with base via C‐N cleavage of benzyl ammonium salts. This reaction features mild conditions and good substrates compatibility to afford thioethers in moderate to good yields.
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