Synthesis of benzyl cinnamate by enzymatic esterification of cinnamic acid

Wang, Yun; Zhang, Dong‐Hao; Chen, Na; Zhi, Gao‐Ying

doi:10.1016/j.biortech.2015.09.028

Cited by 50 publications

(56 citation statements)

References 34 publications

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“…This is consistent with the results obtained by Badgujar and Bhanage (2004), who established an optimum of 55°C for the biotransformation of geraniol with vinyl acetate. This could be attributed to the reduction in density and viscosity of the reaction mixtures at elevated temperatures leading to an increase in the conversion at higher temperatures (Wang et al, 2015). From our data it can be noted that with further increase of temperature beyond 55°C, the conversion of rutin ester in acetone system reduced significantly (Fig.…”

Section: Effect Of Reaction Temperaturementioning

confidence: 77%

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Lipase mediated synthesis of rutin fatty ester: Study of its process parameters and solvent polarity

2017

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Section: Effect Of Reaction Temperaturementioning

confidence: 77%

“…5A). This could be attributed to the overcrowding of immobilised enzyme beads that result in reduction of effective collision among the molecules (He et al, 2012;Wang, Zhang, Chen, & Zhi, 2015). Thus, the mass transfer rate between substrates and enzymes reduces drastically, yielding poor esterification.…”

Section: Effect Of Enzyme Loadmentioning

confidence: 94%

Lipase mediated synthesis of rutin fatty ester: Study of its process parameters and solvent polarity

2017

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“…Similar results were also reported by Martins [21] for the production of butyl butyrate via TLIM-catalyzed reaction. It is reported that an increase in temperature may cause a loss of enzyme activity [22]. For temperatures higher than 50 8C the yield of sucrose erucate decreased as the activity of lipase decreased.…”

Section: Effect Of Temperaturementioning

confidence: 99%

Enzymatic Synthesis and Characterization of Sucrose Erucate

Jadhav¹,

Pratap²

2017

Tenside Surfactants Detergents

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The enzyme catalyzed synthesis is a environmentally friendly route compared to traditional syntheses. The lipase-catalyzed synthesis of sucrose erucate was achieved in a solvent mixture of t-butanol and dimethyl sulfoxide (4 : 1) by esterification of sucrose with erucic acid using the immobilized Thermomyces lanuginosus lipase. Various process parameters like temperature, substrate molar ratio, solvent, time, and enzyme loading were studied. The optimal conditions for the esterification reaction obtained were 10 %(w/w) enzyme loading, a molar ratio sucrose/fatty acid 1 : 1, mild reaction conditions (50 8C and atmospheric pressure) and reaction time (40 h with 55.6 % conversion). The sugar esters were characterized for surfactant properties at different concentration. Sucrose erucate showed a surface tension of (32.73 ± 0.01) mN m -1 at a critical micellar concentration of 9.8 · 10 -5 mol L -1 and good emulsification power.

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“…Therefore, immobilized enzymes that are stable under various conditions are preferred for use in industry [17]. Recently, the synthesis of esters, such as isoamyl acetate, benzyl cinnamate, and phenethyl acetate, from organic acids and alcohols using immobilized enzymes has been reported [18][19][20].…”

Section: Introductionmentioning

confidence: 99%

“…In addition, some of these methods, such as microwave irradiation, cannot be applied on a large scale; as such, developing high-yield, scalable methods for the enzymatic synthesis of formate esters using lipases could prove invaluable. Although lipase-based ester synthesis has been studied [11,15,19], little is known about the enzymatic synthesis of formate esters. For example, Janssen et al [4] reported the lipase-catalyzed transesterification of ethyl formate with octanol to produce octyl formate.…”

Section: Introductionmentioning

confidence: 99%

Novel and Efficient Synthesis of Phenethyl Formate via Enzymatic Esterification of Formic Acid

et al. 2020

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Current methods for the production of esters, including chemical synthesis and extraction from natural sources, are hindered by low yields and environmental pollution. The enzymatic synthesis of these compounds could help overcome these problems. In this study, phenethyl formate, a commercially valuable formate ester, was synthesized using commercial immobilized lipases. The effects of specific enzymes, enzyme concentration, formic acid:phenethyl alcohol molar ratio, temperature, and solvent were studied in order to optimize the synthesis conditions, which were identified as 15 g/L of Novozym 435 enzyme, a 1:5 formic acid:phenethyl alcohol molar ratio, a 40 °C reaction temperature, and 1,2-dichloroethane as the solvent. Under these conditions, phenethyl formate was obtained in a conversion yield of 95.92%. In addition, when 1,2-dichloroethane was replaced with toluene as the solvent, the enzyme could be recycled for at least 20 reactions with a steady conversion yield above 92%, testifying to the economic aspects of the process. The enzymatic synthesis of phenethyl formate using the proposed method is more environmentally friendly than methods currently employed in academic and laboratory settings. Moreover, the method has the potential to enhance the value-added properties of formic acid owing to its downstream use in the production of commercially essential esters.

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Synthesis of benzyl cinnamate by enzymatic esterification of cinnamic acid

Cited by 50 publications

References 34 publications

Lipase mediated synthesis of rutin fatty ester: Study of its process parameters and solvent polarity

Lipase mediated synthesis of rutin fatty ester: Study of its process parameters and solvent polarity

Enzymatic Synthesis and Characterization of Sucrose Erucate

Novel and Efficient Synthesis of Phenethyl Formate via Enzymatic Esterification of Formic Acid

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