Synthesis of Benzoxazino-and Naphthoxazinoquinoline Derivatives as Possible Antitumor Agents

Nasr, Mohamed; Abbasi, M. M.; Nabih, I.

doi:10.1002/jps.2600630837

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Cited by 4 publications

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“…In view of that awaits further investigation and in multiple tumour types, there are being actively investigated for numerous novel therapies against critical nodes of this pathway in the clinic [3]. So many boffins prepared a series of quinoline derivatives, and they research their differential tissue staining and tumor growth retardation to determine antitumor activity [4][5].…”

Section: Introductionmentioning

confidence: 99%

Synthesis of 4-chloro-6-methoxy-2-methyl-3-nitroquinoline

Zhao¹,

Lei²,

Guo³

2017

Proceedings of the 2016 7th International Conference on Education, Management, Computer and Medicine (EMCM 2016)

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Abstract.4-Chloro-6-methoxy-2-methyl-3-nitroquinoline (1) was synthesized from 4-methoxyaniline through three steps including Cyclization, Nitrification and Chlorination. The structure of the target product (1) was confirmed by 1H NMR and MS. This method started with cheap raw materials was of simple experimental operation and mild reaction conditions. It was suitable for large scale pilot study and the yield of the product is achieved to 85%.

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Section: Introductionmentioning

confidence: 99%

Synthesis of 4-chloro-6-methoxy-2-methyl-3-nitroquinoline

Zhao¹,

Lei²,

Guo³

2017

Proceedings of the 2016 7th International Conference on Education, Management, Computer and Medicine (EMCM 2016)

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“…The major diastereomer 4a was separated by crystallization, and its structure and stereochemistry were unequivocally confirmed by single-crystal X-ray analysis (Figure ) . Notably, some oxazinoquinoline derivatives are known to exhibit antimalarial activity and a few of them are possibly antitumor agents …”

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confidence: 99%