Synthesis of benzo[h]quinolone and benzo[c]acridinone derivatives by Fe₃O₄@PS‐Arginine[HSO₄] as an efficient magnetic nanocatalyst

Abstract

Fe 3 O 4 magnetic nanoparticles were synthesized and functionalized by propylsilan and after that arginine. The synthesized Fe 3 O 4 @PS-Arginine magnetic nanoparticles were modified to obtain Fe 3 O 4 @PS-Arg[HSO 4 ]. These nanoparticles were used as environmental friendly solidacid magnetic nanocatalyst for the synthesis of 2-amino-4-arylbenzo[h]quinoline-3-carbonitrile and 10,10-dimethyl-7-aryl-9,10,11,12-tetrahydrobenzo[c]acridin-8(7H)-one derivatives via the one-pot reaction of α-naphthilamine and aromatic aldehydes with malononitrile or dimedone. Simple operation, high reaction yields, reusability of catalyst for several times, short reaction time and easy separation from reaction mixture are the key advantages of using this catalyst.

Synthesis of some derivatives of 1,8-dioxo-octa-hydro xanthene and 9-aryl-hexahydro acridine-1,8-dione using metal ion-exchanged NaY zeolite as heterogeneous catalyst

“…Magnetic acid nanocatalyst for synthesizing of 2-amino-4-aryl benzoquinoline-3-carbonitrile and 10,10-dimethyl-7-aryl-9,10,11,12-tetrahydrobenzo acridin-8(7 H )-one via alpha-naphthylamine and aromatic aldehydes were prepared with malononitrile or dimedone. 35 In 2020, Daraie et al performed the selective chemical synthesis of drug-like pyrrolo[2,3,4- kl ] acridin-1-one using polyoxometalate@lanthanoid catalyst and dimedone, isatin and aniline under green conditions. 36 In 2020, Kamat et al prepared various derivatives of xanthene and coumarin with the help of beta-cyclodextrin as a reusable catalyst at 70 °C in water.…”

Synthesis and antimicrobial evaluation of novel tris‐thiadiazole derivatives

“…In continuation of our work concerning the synthesis of aza‐heterocyclic compounds [40–45] and study some of their medicinal properties [46–49], in the present study, we planned an efficient procedure for synthesis of novel 1,1′,1″‐(((1,3,5‐triazine‐2,4,6‐triyl) tris (oxy)) tris (benzene‐4,1‐diyl)) tris (2‐((5‐((1‐arylethylidene)amino)‐1,3,4‐thiadiazol‐2‐yl)thio)ethan‐1‐one) derivatives 6a–h via the reaction of 5‐((1‐arylethylidene)amino)‐1,3,4‐thiadiazole‐2‐thiol 5a–h with 1,1′,1″‐(((1,3,5‐triazine‐2,4,6‐triyl) tris (oxy)) tris (benzene‐4,1‐diyl)) tris (2‐bromoethan‐1‐one) 2 . Also, the antimicrobial potency of synthesized compounds were studied.…”

FeCl3‐Catalyzed Highly Diastereoselective Synthesis of Polyhydrobenzo[a]acridinones

“…As a consequence, the synthesis of benzoacridinone or polyhydrobenzoacridinone derivatives has attracted considerable attention. The condensations of aldehydes, naphthylamines and cyclic 1, 3‐diketones have been well studied to synthesize polyhydrobenzo[ c ]acridinone derivatives containing the dihydropyridines (Scheme 1a) [4a–l] . The reactions of imines and cyclic 1,3‐diketones produced polyhydrobenzo[ a ]acridinone derivatives containing the dihydropyridines [4m–o] .…”