Synthesis of Benzo[e][1,4,3]oxathiazin-3-one 1-Oxides from NH-S-(2-Hydroxyaryl)sulfoximines
Kiruthika Periasamy,
Pit van Bonn,
Runa Tschekorsky Orloff
et al.
Abstract:Cyclizations
of NH-S-(2-hydroxyaryl)sulfoximines
with 1,1′-carbonyldiimidazol (CDI) give unprecedented benzo[e][1,4,3]oxathiazin-3-one 1-oxides in good yields. The standard
synthetic protocol involves the use of DCE at an increased temperature
for 16 h. Under mechanochemical conditions, a representative product
was obtained without a solvent at ambient temperature in only 60 min.
X-ray single-crystal structure analysis confirmed the molecular scaffold
representing a three-dimensional heterocycle.
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