Synthesis of benzimidazole by mortar–pestle grinding method

Zhang, Peng; Liu, Caiqin; Yu, Ling; Hou, Huiqing; Sun, Wei‐Ming; Fang, Ke

doi:10.1080/17518253.2021.1991483

Cited by 11 publications

(8 citation statements)

References 16 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…With truxene-based aldehydes (TX-CHO) and 3,3′-diaminobenzidine (DAB) as the starting materials and acetic acid as the promoter, benzimidazole-bridged conjugated porous polymer (TX-BI-POP) was synthesized via a ball-milling process for 2 h in a planetary ball mill at room temperature (Scheme ). , This mechanochemical method proceeded via a polycondensation, cyclization, and oxidation cascade sequence. After purifications, the deep yellow solid was submitted to a series of standard characterizations (Figure ).…”

Section: Resultsmentioning

confidence: 99%

Mechanochemical Construction of Benzimidazole-Bridged Conjugated Porous Polymer Toward Versatile Photocatalysis

Hu,

Zhou,

Huang

et al. 2023

ACS Sustainable Chem. Eng.

View full text Add to dashboard Cite

Conjugated porous polymers (CPPs) have found rapidly expanding applications in a wide range of research areas. However, most of the reported CPPs are constructed through thermochemistry, which often requires transition metals or harsh reaction conditions. Here we report a highly efficient and environmentally friendly mechanochemical approach to synthesize benzimidazole-bridged conjugated porous polymer (TX-BI-POP) via a ring-formation strategy. More importantly, the resultant TX-BI-POP exhibits excellent photocatalytic performance and can be applied as a rare versatile metal-free and reusable photocatalyst. Specifically, the synthetic utility of TX-BI-POP has been illustrated in three types of mechanistically distinct prototypic organic transformations: net oxidative hydroxylation of arylboronic acids, redox neutral bromoalkylation of unactivated terminal alkenes, and net reductive pinacol C–C coupling. This work not only provides a green and sustainable way to access porous materials but also opens a new class of versatile metal-free heterogeneous photocatalysts for organic transformations.

show abstract

Section: Resultsmentioning

confidence: 99%

Mechanochemical Construction of Benzimidazole-Bridged Conjugated Porous Polymer Toward Versatile Photocatalysis

Hu,

Zhou,

Huang

et al. 2023

ACS Sustainable Chem. Eng.

View full text Add to dashboard Cite

show abstract

“…On the other hand, mechanochemical synthesis is emerging as new green method for the preparation of various heterocycles via C-O, C-N, and C-S bond formation through methods like grinding and sonication. [11][12][13][14][15][16][17][18] The simple economical method offers several benefits such as less use of harmful toxic solvents, use of eco-friendly chemicals, less use of toxic and expensive metal-based catalyst, lesser release of harmful wastes and no or negligible byproduct formation. [19][20][21] Since the reaction does not result in the formation of any byproduct, the yield of the reaction is also remarkably higher as compared to conventional methods employed.…”

Section: Letter Synopenmentioning

confidence: 99%

A Facile, Mechanochemical, Solvent-, and Catalyst-Free Synthesis of Functionalized 4-Thiazolidinones

Bhargava,

Wahan,

Chawla

et al. 2023

SynOpen

View full text Add to dashboard Cite

A highly eco-friendly greener approach based on the mechanochemical method using mortar and pestle is explored for the preparation of a variety of functionalized 4-thiazolidinones. The developed methodology does not require the use of harmful or expensive reagents and organic solvents and requires very less reaction time with easy isolation. The explored greener approach for the synthesis of 4-thiazolidinones is an important in terms of their usefulness for their valuable pharmacological properties.

show abstract

“…In their work, the authors reported the synthesis of fenbendazole, a broad‐spectrum, low‐toxicity anthelmintic, via the condensation of a diamine 8 and formamide in the presence of a catalytic amount of acetic acid, which makes it possible to avoid metals at this stage in order to form the benzimidazole unit 9 in 85 % yield (Scheme 20). [61] However, the second step of fenbendazole synthesis was performed in DMF using copper as catalyst. The solvent‐free methodology was also applicable to benzothiazole and benzoxazole, a motif often found in biologically active compounds.…”

Section: Mechanosynthesis Of Biologically Active Heterocyclic Compoundsmentioning

confidence: 99%

Sustainable Mechanosynthesis of Biologically Active Molecules

et al. 2022

View full text Add to dashboard Cite

Synthetic mechanochemistry, the use of mechanical force produced by milling, grinding or extruding, as an activation technique, provides access to chemical entities of all kinds. This Review is focused on examples reported so far of known Active Pharmaceutical Ingredients (APIs), and effectively evaluated bioactive molecules, all prepared by mechanosynthesis. Three families of molecules are discussed: heterocyclic compounds, metal complexes and peptides. Advantages of the mechanochemistry approach are highlighted especially from a green chemistry and efficacy point of view.

show abstract

Synthesis of benzimidazole by mortar–pestle grinding method

Cited by 11 publications

References 16 publications

Mechanochemical Construction of Benzimidazole-Bridged Conjugated Porous Polymer Toward Versatile Photocatalysis

Mechanochemical Construction of Benzimidazole-Bridged Conjugated Porous Polymer Toward Versatile Photocatalysis

A Facile, Mechanochemical, Solvent-, and Catalyst-Free Synthesis of Functionalized 4-Thiazolidinones

Sustainable Mechanosynthesis of Biologically Active Molecules

Contact Info

Product

Resources

About