Synthesis of benzannulated spiroacetals using chiral gold–phosphine complexes and chiral anions

One-Pot Synthesis and Conformational Analysis of Six-Membered Cyclic Iodonium Salts

“…The analytical data is in accordance with literature data. [5] ( 9, 143.2, 136.6, 135.0, 134.5, 122.3, 92.8. FTIR (ATR, neat) = 3079, 1702, 1668, 1459, 1294, 1248, 1096, 1015.…”

“…An important subclass of HVIs are diaryl- 3 -iodanes or diaryliodonium salts (DIS, 1, Figure 1). [5] Bearing iodobenzene as potent leaving group (hypernucleofug) [6] they have become frequently utilized reagents in a plethora of C(sp n )-H and Het-H arylation reactions. [7] Despite their outstanding performance as electrophilic group transfer reagents in transition metal-mediated and metal-free arylations their time-consuming multi-step synthesis often impedes their application.…”

Enantioselective synthesis of spiroacetals: the conquest of a long-sought goal in asymmetric catalysis

“…15 A regioisomeric mixture of spiroacetals 11 and 12 was obtained independently of the catalytic system used. Formation of this mixture is easily explained considering that the reaction proceeds through the initial coordination of the gold complex to the alkyne.…”

(R)- and (S)-2,2′-Bis(diphenylphosphino)-6,6′-dimethoxy-1,1′-biphenyl

“…An asymmetric gold-catalyzed dihydroalkoxylation of alkynes for the synthesis of benzannulated spiroacetals has been investigated in the presence of several phosphine ligands. The association of MeOBIPHEP ligand with the chiral silver salt AgTRIP led to the best results (eq 78) 104. …”