Synthesis of aza-Henry products and enamines in water by Michael addition of amines or thiols to activated unsaturated compounds

Conjugate addition nitro-Mannich reaction of carbon and heteroatom nucleophiles to nitroalkenes

“…By analogy to the literature, performing the reaction in water worked well (68%, Entry 3). 46 The electron withdrawn para-nitroaniline was unreactive under both sets of conditions, but deprotonation with n BuLi and subsequent addition to nitroalkene 2 gave the desired 1,4-addition product 29 in 45% yield (entry 4). Reaction with morpholine in CH 2 Cl 2 at rt gave complete consumption of starting material, but only a small yield (22%) of 1,4-addition product 30 was isolated (entry 5).…”

One‐pot Three‐component Route for the Synthesis of Functionalized 4H‐chromenes Catalyzed by ZrOCl2·8H2O in Water

“…As a part of our continued interest in the development of practical, safe, and environmentally friendly procedures for some important organic transformations and synthesis of chromenes , a convenient and facile one‐pot three‐component method for the synthesis of 4 H ‐chromenes in the presence of ZrOCl 2 ·8H 2 O as catalyst in water under thermal condition has been described (Scheme ).…”

Bulk Gold-Catalyzed Reactions of Diazoalkanes with Amines and O2 to Give Enamines

“…10) (see Electronic Supplementary Material). The configurations of the (E)-and (Z)-isomers were established by comparison of their 1 H NMR spectral data with those of the dimethyl analogs reported by Vernon [58,59], Dolfini [62], and Saidi [63]. The (E)-enamines show a singlet near 4.7 ppm for the olefinic proton, while the (Z)-isomers show a singlet at about 5.1 ppm.…”