Synthesis of asymmetrical β-diketiminate magnesium methyl complexes and their catalytic application in cyanosilylation of ketones

Hydroboration and hydrosilylation of alkenes catalyzed by an unsymmetrical magnesium methyl complex

“…40–43 Quite recently, we reported the synthesis of a series of unsymmetrical β-diketiminate magnesium methyl complexes that were successfully employed as highly efficient catalysts in the cyanosilylation of ketones including natural products with a low catalyst loading (0.2 mol%) under solvent-free conditions at room temperature. 44 We wondered whether this could be applicable to the challenging hydroboration and hydrosilylation of more inert alkenes. To our delight, it provided a high isolated yield and high regioselectivity under mild reaction conditions (Fig.…”

Mononuclear Aluminum Complexes as Precursors for Cyanosilylation of Carbonyl Compounds

“…[13,14] The cyanosilylation reaction of aldehydes and ketones with trimethylsilyl cyanide (TMSCN) has recently emerged as an efficient and sustainable route to construct a new carbonÀ carbon bond, resulting in the formation of α-hydroxy nitrile derivatives. [15][16][17] The transformation of α-hydroxy nitrile derivatives into various intermediate compounds facilitates the synthesis of several building blocks such as α-hydroxy ketones, β-amino alcohols, and α-hydroxy acids, which are used in the production of fine chemicals, agrochemicals, and pharmaceuticals. [18] Literature survey reveals that transition metal complexes-based catalytic systems have been widely employed in the cyanosilylation of aldehydes and ketones.…”