Synthesis of Asp-based lactam cyclic peptides using an amide-bonded diaminodiacid to prevent aspartimide formation
Wen-Jie Li,
Jun-You Chen,
Hui-Xia Zhu
et al.
Abstract:Asp-based lactam cyclic peptides are considered promising drug candidates. However, Fmoc solid-phase synthesis (Fmoc-SPPS) synthesized these peptides with aspartimide formation, resulting in low yields or even failure to obtain the...
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