Abstract:The tetralone analogues of podophyllotoxin were synthesized by the chalcone route. This route attracts the attention because of its simple operating conditions and easy availability of the chemicals. Initially, chalcones were prepared in high yields by Claisen-Schmidt reaction of acetophenones derivatives with 3,4,5-trimethylthoxybenzaldehyde. The cyclopropyl ketones were prepared in good yields by Simmon-Smith reaction of chalcones with diiodomethane with Zn-Cu couple in presence of ether. Tetralones were pre… Show more
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