Synthesis of arbutin–gold nanoparticle complexes and their enhanced performance for whitening

Park, Jin Ju; Hwang, Su Jung; Kang, Yu Sun; Jung, Junho; Park, Suryeon; Hong, Jimin; Park, Youmie; Hj, Lee

doi:10.1007/s12272-019-01164-7

Cited by 24 publications

(15 citation statements)

References 27 publications

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“…In various studies, it is revealed that arbutin formulations can be useful for the treatment of various diseases due to its multi‐target biological effects such as treatment of hyperpigmentation disorders (Ayumi, Sahudin, Hussain, Hussain, & Samah, 2019; Park et al, 2019), anti‐diabetic (Lv et al, 2019), wound healing (Polouliakh et al, 2020), anti‐osteoporosis (Bonifacio et al, 2020), treatment of acute lung injury (Ye et al, 2019), management of cardiac hypertrophy (Nalban et al, 2020), anticancer (Jiang et al, 2018; Safari et al, 2020; Wang, Wang, Li, Zhang, & Wang, 2020), antioxidant activity (Bonifacio et al, 2020), treatment of optic nerve injury (Ebrahim‐Tabar, Nazari, Pouramir, Ashrafpour, & Pourabdolhossein, 2020; Zhao, Wang, Qin, & Wang, 2019), treatment of central nervous system disorders (Ahmadian, Ghasemi‐Kasman, Pouramir, & Sadeghi, 2019; Dastan et al, 2019; Ding et al, 2020), hepatoprotective activity (Mirshahvalad et al, 2016), effect on human mesenchymal stem cells (Bonifacio et al, 2020; Jamil, Crowe, Tablin, & Oliver, 2005), radioprotective effect (Nadi, Elahi, Moradi, & Banaei, 2019), antimicrobial (Nadi et al, 2019), antiaging (Zhou et al, 2017), antitussive (Koul, Kumar, Yadav, & Jin, 2020), diuretic (Myagchilov, Mineev, Sokolova, Gerdasova, & Gorovoi, 2020), anti‐inflammatory (Lee & Kim, 2012; Zhou, Zhao, Li, & Reetz, 2019), inhibitory effects on melanin formation (Li, Du, & Du, 2018), estrogen‐like effects (Zeng et al, 2018), and cytoprotective effects (Seyfizadeh et al, 2012) etc.…”

Section: Chemical Characterizations and Therapeutic Effects Of Arbutin In Cosmetic And Pharmaceutical Preparationsmentioning

confidence: 99%

“…This animal model is used for bioactive and depigmenting agents such as arbutin and kojic acid too. Depigmenting assay by in vitro (i.e., melanocytes) and in vivo (i.e., mice) models along with zebrafish model can lead to a better understanding of the effectiveness of antimelanogenic agents and better and safe development of these lightening agents (Lajis et al, 2012; Lee et al, 2018; Park et al, 2019). Findings from these investigations highlighted the importance of zebrafish used as an alternative model in the antimelanogenic evaluations of cosmetics ingredients because of similar gene sequences to humans.…”

Section: Use Of Zebrafish Model (In Vivo) For Screening Of Alpha‐arbutin and Other Skin Lightening Agents In Cosmeticmentioning

confidence: 99%

“…In an in vivo study, Park et al designed arbutin–gold nanoparticle complexes. They exhibited that these nanoparticles have very stronger whitening effect than arbutin and can be used as a new therapeutic strategy for the development of novel anti‐pigmenting agents (Park et al, 2019).…”

Section: Nano‐phytotherapy—a Potential Strategy For Increasing Bioavailability Of Arbutinmentioning

confidence: 99%

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A comprehensive review of the therapeutic potential of α‐arbutin

Saeedi

Khezri

Zakaryaei

et al. 2021

Phytotherapy Research

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Cosmetic dermatology preparations such as bleaching agents are ingredients with skin‐related biological activities for increasing and improving skin beauty. The possibility of controlling skin hyperpigmentation disorders is one of the most important research goals in cosmetic preparations. Recently, cosmetics containing herbal and botanical ingredients have attracted many interests for consumers of cosmetic products because these preparations are found safer than other preparations with synthetic components. However, high‐quality trial studies in larger samples are needed to confirm safety and clinical efficacy of phytotherapeutic agents with high therapeutic index. Arbutin (p‐hydroxyphenyl‐β‐d‐glucopyranoside) is a bioactive hydrophilic polyphenol with two isomers including alpha‐arbutin (4‐hydroxyphenyl‐α‐glucopyranoside) and β‐arbutin (4‐hydroxyphenyl‐β‐glucopyranoside). It is used as a medicinal plant in phytopharmacy. Studies have shown that alpha‐arbutin is 10 times more effective than natural arbutin. A comparison of IC50 values showed that α‐arbutin (with concentration 2.0 mM) has a more potent inhibitory activity on human tyrosinase against natural arbutin (with higher concentration than 30 mM). A review of recent studies showed that arbutin could be beneficial in treatment of various diseases such as hyperpigmentation disorders, types of cancers, central nervous system disorders, osteoporosis, diabetes, etc. This study was designed to describe the therapeutic efficiencies of arbutin.

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Section: Chemical Characterizations and Therapeutic Effects Of Arbutin In Cosmetic And Pharmaceutical Preparationsmentioning

confidence: 99%

Section: Use Of Zebrafish Model (In Vivo) For Screening Of Alpha‐arbutin and Other Skin Lightening Agents In Cosmeticmentioning

confidence: 99%

Section: Nano‐phytotherapy—a Potential Strategy For Increasing Bioavailability Of Arbutinmentioning

confidence: 99%

See 1 more Smart Citation

A comprehensive review of the therapeutic potential of α‐arbutin

Saeedi

Khezri

Zakaryaei

et al. 2021

Phytotherapy Research

View full text Add to dashboard Cite

show abstract

“…In the case of P. Anatolica , which is endemic to Turkey, the leaves and branches showed higher levels of arbutin than fruits (4.74, 4.46, and 0.11%, respectively) [ 107 ]. In addition, arbutin-conjugated gold nanoparticles displayed enhanced whitening capabilities, compared to arbutin itself [ 108 ].…”

Section: Functional Uses Of Pearsmentioning

confidence: 99%

A review of pears (Pyrus spp.), ancient functional food for modern times

Hong

Lansky²,

Kang

et al. 2021

BMC Complement Med Ther

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Background Pears have been world-widely used as a sweet and nutritious food and a folk medicine for more than two millennia. Methods We conducted a review from ancient literatures to current reports to extract evidence-based functions of pears. Results We found that pears have many active compounds, e.g., flavonoids, triterpenoids, and phenolic acids including arbutin, chlorogenic acid, malaxinic acid, etc. Most of researchers agree that the beneficial compounds are concentrated in the peels. From various in vitro, in vivo, and human studies, the medicinal functions of pears can be summarized as anti-diabetic,-obese, −hyperlipidemic, −inflammatory, −mutagenic, and -carcinogenic effects, detoxification of xenobiotics, respiratory and cardio-protective effects, and skin whitening effects. Therefore, pears seem to be even effective for prevention from Covid-19 or PM2.5 among high susceptible people with multiple underlying diseases. Conclusion For the current or post Covid-19 era, pears have potential for functional food or medicine for both of communicable and non-communicable disease.

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“…Arbutin, kojic acid, azelaic acid, glycolic acid, resveratrol, and epigallocatechin gallate are major natural tyrosinase inhibitors which have been reported to produce a skin-lightening effect and/or anti-neurodegenerative activity by inhibiting the conversion of L-tyrosine into L-DOPA, and are known to be outstanding antioxidants [13][14][15][16]. Among them, arbutin, a phenolic glycoside, has been commonly applied to skin-lightening cosmetic products and suggested as a candidate for the treatment of Parkinson's disease [13,17]. Numerous studies have suggested industrial production of arbutin through chemical synthesis [18], extraction from plants [12], and microbial enzymatic biotransformation [19].…”

Section: Introductionmentioning

confidence: 99%

Tyrosinase Inhibitory Activity of Soybeans Fermented with Bacillus subtilis Capable of Producing a Phenolic Glycoside, Arbutin

2020

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The production of arbutin, an effective tyrosinase inhibitor as well as an outstanding antioxidant, by 691 Bacillus strains isolated from soybean-based foods was tested to enhance the tyrosinase inhibitory activity of soybeans via fermentation with the strains. Among the strains tested, the 5 strains capable of significantly producing arbutin were identified as B. subtilis via 16S rRNA sequencing. When soybeans were fermented with each of the selected strains, the arbutin content was highest on day 1 of fermentation and decreased thereafter. However, the tyrosinase inhibitory activity of the fermented soybeans continuously increased as fermentation progressed, whereas the activity of non-inoculated soybeans was consistently low. The results indicate that arbutin enhances the tyrosinase inhibitory activity of soybeans in the early period of fermentation, while other substances besides arbutin contribute to the activity in the later period. Consequently, soybeans fermented with arbutin-producing B. subtilis strains could be considered as a natural source of cosmeceuticals and nutricosmetics used in skin lightening and may be of interest in the food industry because they contain well-known and powerful antioxidants such as arbutin and other substances.

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Synthesis of arbutin–gold nanoparticle complexes and their enhanced performance for whitening

Cited by 24 publications

References 27 publications

A comprehensive review of the therapeutic potential of α‐arbutin

A comprehensive review of the therapeutic potential of α‐arbutin

A review of pears (Pyrus spp.), ancient functional food for modern times

Tyrosinase Inhibitory Activity of Soybeans Fermented with Bacillus subtilis Capable of Producing a Phenolic Glycoside, Arbutin

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