Synthesis of apo-13- and apo-15-lycopenoids, cleavage products of lycopene that are retinoic acid antagonists

Narayanasamy, Sureshbabu; Sun, Jun; Pavlovicz, Ryan E.; Eroglu, Abdulkerim; Rush, Cassandra; Sunkel, Benjamin; Li, Chenglong; Harrison, Earl H.; Curley, Robert W.

doi:10.1194/jlr.d073148

Cited by 18 publications

(15 citation statements)

References 36 publications

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“…In the liver and intestine, FXR is expressed at high levels, and forms a heterodimer with RAR. The apolycopenoids resulting from the cleavage products of lycopene from tomato juice could be present in the liver at low concentrations and could act as ligands of the RAR [ 51 , 52 ]. When RAR heterodimerizes with other receptors, like FXR, it is involved in the regulation of its partner receptor’s pathways, such as bile acids, lipid, and glucose metabolism.…”

Section: Discussionmentioning

confidence: 99%

Tomato Juice Supplementation Influences the Gene Expression Related to Steatosis in Rats

et al. 2018

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The objective of this work was to identify the effect of tomato juice on the expression of genes and levels of metabolites related to steatosis in rats. Male Sprague Dawley rats (8 weeks-old) were grouped (6 rats/group) in four experimental groups: NA (normal diet and water), NL (normal diet and tomato juice), HA (high-fat diet and water), and HL (high-fat diet and tomato juice). After an intervention period of 5 weeks, rats were sacrificed and biochemical parameters, biomarkers of oxidative stress, liver metabolites, and gene expression were determined. Although the H diet provoked dislipemia related to steatosis, no changes in isoprostanes or liver malondialdehyde (MDA) were observed. Changes in the gene expression of the HA group were produced by the high consumption of fat, whereas the consumption of tomato juice had different effects, depending on the diet. In the NL group, the genes involved in β-oxidation were upregulated, and in groups NL and HL upregulation of CD36 and downregulation of APOB and LPL were observed. In addition, in the HL group the accumulation of lycopene upregulated the genes FXR and HNF4A, which have been suggested as preventive factors in relation to steatosis. Regarding the metabolomics study, intake of tomato juice stimulated the biosynthesis of glutathione and amino acids of the transulfurization pathway, increasing the levels of metabolites related to the antioxidant response.

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Section: Discussionmentioning

confidence: 99%

Tomato Juice Supplementation Influences the Gene Expression Related to Steatosis in Rats

et al. 2018

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“…Whether all BCO2- derived apocarotenoids can act as RAR ligands is not clear. Some studies show that some apocarotenoids do not bind RARs [67], while other studies suggest that some of them can act as RAR antagonists [68,69] (Figure 1).…”

Section: β-Carotene and Obesity; Key Findings And Technical Limitamentioning

confidence: 99%

β-carotene in Obesity Research: Technical Considerations and Current Status of the Field

2019

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Over the past decades, obesity has become a rising health problem as the accessibility to high calorie, low nutritional value food has increased. Research shows that some bioactive components in fruits and vegetables, such as carotenoids, could contribute to the prevention and treatment of obesity. Some of these carotenoids are responsible for vitamin A production, a hormone-like vitamin with pleiotropic effects in mammals. Among these effects, vitamin A is a potent regulator of adipose tissue development, and is therefore important for obesity. This review focuses on the role of the provitamin A carotenoid β-carotene in human health, emphasizing the mechanisms by which this compound and its derivatives regulate adipocyte biology. It also discusses the physiological relevance of carotenoid accumulation, the implication of the carotenoid-cleaving enzymes, and the technical difficulties and considerations researchers must take when working with these bioactive molecules. Thanks to the broad spectrum of functions carotenoids have in modern nutrition and health, it is necessary to understand their benefits regarding to metabolic diseases such as obesity in order to evaluate their applicability to the medical and pharmaceutical fields.

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“…Among them, α-carotene, β-carotene, β-cryptoxanthin, lycopene, lutein, and zeaxanthin are the major dietary carotenoids found in human plasma [ 7 ]. While α-carotene, β-carotene and β-cryptoxanthin are provitamin A carotenoids, meaning they can be metabolized to retinol, lycopene, lutein and zeaxanthin cannot be converted to vitamin A [ 8 ]. Provitamin A carotenoids may be particularly important dietary sources for maintaining vitamin A status in impoverished regions, such as in rural Southern Asia [ 9 ], where vitamin A deficiency (VAD) has been shown to affect 20–35% of young children, school-aged adolescents and women of reproductive age [ [10] , [11] , [12] ] and is widely associated with low intakes of carotenoid-rich foods such as dark green leaves, yellow and orange vegetables and fruits and egg [ 12 ].…”

Section: Introductionmentioning

confidence: 99%

Plasma proteins associated with circulating carotenoids in Nepalese school-aged children

Eroglu

Schulze

Yager

et al. 2018

Archives of Biochemistry and Biophysics

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Carotenoids are naturally occurring pigments that function as vitamin A precursors, antioxidants, anti-inflammatory agents or biomarkers of recent vegetable and fruit intake, and are thus important for population health and nutritional assessment. An assay approach that measures proteins could be more technologically feasible than chromatography, thus enabling more frequent carotenoid status assessment. We explored associations between proteomic biomarkers and concentrations of 6 common dietary carotenoids (α-carotene, β-carotene, lutein/zeaxanthin, β-cryptoxanthin, and lycopene) in plasma from 500 6–8 year old Nepalese children. Samples were depleted of 6 high-abundance proteins. Plasma proteins were quantified using tandem mass spectrometry and expressed as relative abundance. Linear mixed effects models were used to determine the carotenoid:protein associations, accepting a false discovery rate of q < 0.10. We quantified 982 plasma proteins in >10% of all child samples. Among these, relative abundance of 4 were associated with β-carotene, 11 with lutein/zeaxanthin and 51 with β-cryptoxanthin. Carotenoid-associated proteins are notably involved in lipid and vitamin A transport, antioxidant function and anti-inflammatory processes. No protein biomarkers met criteria for association with α-carotene or lycopene. Plasma proteomics may offer an approach to assess functional biomarkers of carotenoid status, intake and biological function for public health application.Original maternal micronutrient trial from which data were derived as a follow-up activity was registered at ClinicalTrials.gov: NCT00115271.

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Synthesis of apo-13- and apo-15-lycopenoids, cleavage products of lycopene that are retinoic acid antagonists

Cited by 18 publications

References 36 publications

Tomato Juice Supplementation Influences the Gene Expression Related to Steatosis in Rats

Tomato Juice Supplementation Influences the Gene Expression Related to Steatosis in Rats

β-carotene in Obesity Research: Technical Considerations and Current Status of the Field

Plasma proteins associated with circulating carotenoids in Nepalese school-aged children

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