Synthesis of Antimicrobial Polymers to Overcome Antimicrobial Resistance

Ahmed, Salauddin

doi:10.25148/etd.fidc006577

Cited by 1 publication

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“…It is expected that the adhesion of HMW antimicrobial polymers to a negatively charged bacterial cell membrane should be highly effective in comparison to the adhesion of LMW antimicrobial polymers. Instead, contradicting results are found, according to which LMW antimicrobial polymers have greater biocidial activity [ 4 ]. Usually for bacterial infections, antibiotics are the most commonly used drug for treatment, which show adverse effects such as reducing immunity, increasing susceptibility to infections, and developing resistance against antimicrobial agents [ 5 ].…”

Section: Introductionmentioning

confidence: 99%

Antimicrobial Peptides and Their Applications in Biomedical Sector

2021

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In a report by WHO (2014), it was stated that antimicrobial resistance is an arising challenge that needs to be resolved. This resistance is a critical issue in terms of disease or infection treatment and is usually caused due to mutation, gene transfer, long-term usage or inadequate use of antimicrobials, survival of microbes after consumption of antimicrobials, and the presence of antimicrobials in agricultural feeds. One of the solutions to this problem is antimicrobial peptides (AMPs), which are ubiquitously present in the environment. These peptides are of concern due to their special mode of action against a wide spectrum of infections and health-related problems. The biomedical field has the highest need of AMPs as it possesses prominent desirable activity against HIV-1, skin cancer, breast cancer, in Behcet’s disease treatment, as well as in reducing the release of inflammatory cells such as TNFα, IL-8, and IL-1β, enhancing the production of anti-inflammatory cytokines such as IL-10 and GM-CSF, and in wound healing properties. This review has highlighted all the major functions and applications of AMPs in the biomedical field and concludes the future potential of AMPs.

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Section: Introductionmentioning

confidence: 99%