Synthesis of antimicrobial monophase silver-doped hydroxyapatite nanopowders for bone tissue engineering

The Properties of Nanosilver – Doped Nanohydroxyapatite Coating On the Ti13zr13Nb Alloy

“…To provide antibacterial properties of the hydroxyapatite coatings, the doping of nanosilver or nanocopper nanoparticles with similar bactericidal effects as antibiotics was investigated [6,19,20]. The bactericidal action of silver was proven for Escherichia coli, Staphylococcus aureus, Staphylococcus albus, Candida albicans and Pseudomonas aeruginosa [21][22][23]. To improve antibacterial properties of nanosilver, the sufficient content of nanosilver concentration around a tissue is needed.…”

Antimicrobial activity of hemocompatible silver doped hydroxyapatite nanoparticles synthesized by modified sol–gel technique

“…A disadvantage of HAp is that, proteins, amino acids, and other organic substances are easily adsorbed, which could create an environment conducive for the growth of bacteria on its surface leading to infection at the implant site, accompanied by decreased penetration of antibiotics and reduced blood supply (Rameshbabu and Prasad Rao 2007). When microorganisms adhere onto implant surfaces, they can form biofilms wherein microorganisms tend to be more resistant to antimicrobial agents (Stanic et al 2011). In addition, the presence of implant materials inside the body interferes with the host defense mechanism and influences the clinical dose of antibiotics that is needed to protect against infections.…”

“…(Diaz et al 2009;Rameshbabu and Prasad Rao 2007;Stanic et al 2011;Zheng et al 2009). In this study crystalline Ag-HAp nanorods have been synthesized at 100°C using a modified sol-gel method followed by dialysis (Jadalannagari et al 2011).…”

“…In view of this, use of inorganic antibacterial agents has attracted interest for control of microbial infections. Doping HAp with antimicrobial metal ions has been exploited to address these issues (Rameshbabu and Prasad Rao 2007;Stanic et al 2011;Xiao et al 2010;Kim et al 2011).…”

“…In addition, the presence of implant materials inside the body interferes with the host defense mechanism and influences the clinical dose of antibiotics that is needed to protect against infections. Moreover, antibiotics loaded in the implant material tend to be quickly washed out by body fluids and cannot prevent long term post surgical infections (Stanic et al 2011;Bahadir et al 2009). Besides, excessive use of antibiotics could lead to the development of resistant microorganisms.…”