Synthesis of an amphiphilic copolymer using biopolymer-dextran <i>via</i> a combination of ROP and RAFT techniques

Karmakar, Puja Das; Pal, Sagar

doi:10.1039/d1py01596f

Cited by 6 publications

(8 citation statements)

References 41 publications

(48 reference statements)

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“…The lower elution time curve of pNVC- b -PEG- b -pNVC 4 confirms that it has the highest molecular weight among all materials. Additionally, the monomodal GPC curves confirmed the formation of copolymers without homo-polymerization …”

Section: Resultsmentioning

confidence: 64%

“…This CRP technique can provide a narrow polydispersity compared with free radical polymerization techniques. Among CRP techniques, reversible addition–fragmentation chain-transfer (RAFT) polymerization is the most efficient tool to prepare block copolymers as it can be accomplished with different monomers and in every case, it develops copolymers with a narrow polydispersity index (PDI) and a controlled molecular weight . Herein, PEG was chosen as the base material owing to its versatility, good water solubility, non-toxicity, biocompatibility, and biodegradability. , Previously, Shubin et al.…”

Section: Introductionmentioning

confidence: 99%

“…Among CRP techniques, reversible addition−fragmentation chain-transfer (RAFT) polymerization is the most efficient tool to prepare block copolymers as it can be accomplished with different monomers and in every case, it develops copolymers with a narrow polydispersity index (PDI) and a controlled molecular weight. 20 Herein, PEG was chosen as the base material owing to its versatility, good water solubility, non-toxicity, biocompatibility, and biodegradability. 21,22 Previously, Shubin et al developed PEG-based hydrogels for the encapsulation of primary submandibular gland (SMG) cells for tissue regeneration.…”

Section: Introductionmentioning

confidence: 99%

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Synthesis and Characterizations of Bioactive Glass Nanoparticle-Incorporated Triblock Copolymeric Injectable Hydrogel for Bone Tissue Engineering

Pal

Karmakar

Vel

et al. 2023

ACS Appl. Bio Mater.

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Recently, injectable hydrogels have attracted much interest in tissue engineering (TE) applications because of their controlled flowability, adaptability, and easy handling properties. This work emphasizes the synthesis and characterizations of bioactive glass (BAG) nanoparticle-reinforced poly(ethylene glycol) (PEG)- and poly(N-vinylcarbazole) (pNVC)-based minimally invasive composite injectable hydrogel suitable for bone regeneration. First, the copolymer was synthesized from a combination of PEG and pNVC through reversible addition–fragmentation chain-transfer (RAFT) polymerization and nanocomposite hydrogel constructs were subsequently prepared by conjugating BAG particles at varying loading concentrations. Gel permeation chromatography (GPC) analysis confirmed the controlled nature of the polymer. Various physicochemical characterization results confirmed the successful synthesis of copolymer and nanocomposite hydrogels that showed good gelling and injectability properties. Our optimal nanocomposite hydrogel formulation showed excellent swelling properties in comparison to the copolymeric hydrogel due to the presence of hydrophilic BAG particles. The bone cell proliferation rate was found to be evidently higher in the nanocomposite hydrogel than in the copolymeric hydrogel. Moreover, the enhanced level of ALP activity and apatite mineralization for the nanocomposite in comparison to that for the copolymeric hydrogel indicates accelerated in vitro osteogenesis. Overall, our study findings indicate BAG particle-conjugated nanocomposite hydrogels can be used as promising grafting materials in orthopedic reconstructive surgeries complementary to conventional bone graft substitutes in cancellous bone defects due to their 3D porous framework, minimal invasiveness, and ability to form any desired shape to match irregular bone defects.

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Section: Resultsmentioning

confidence: 64%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Synthesis and Characterizations of Bioactive Glass Nanoparticle-Incorporated Triblock Copolymeric Injectable Hydrogel for Bone Tissue Engineering

Pal

Karmakar

Vel

et al. 2023

ACS Appl. Bio Mater.

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“…These well-organized selfassemble structures are developed through hydrogen bonding, electrostatic interaction, hydrophobic interactions as well as van der Waals force. [1][2][3][4][5][6] Presently, stimuli-responsive (such as temperature, pH, light, magnetic as well as electric field etc.) copolymers have been highlighted with significant interest for biological cause.…”

Section: Introductionmentioning

confidence: 99%

“…[27][28][29] In the last few decades, many researchers have developed pNIPAM based thermo-sensitive copolymers for drug release study. [5,6,[30][31][32][33][34][35][36] However, to the best of our knowledge, this is the first time where TKP and pNIPAM based graft copolymer have been synthesized through control radical polymerization technique and used as host molecule to study the encapsulation and release behavior of Nile red dye. Previously, many researcher used Nile red as host molecule for encapsulation and release study because it is inexpensive and easy to handle.…”

Section: Introductionmentioning

confidence: 99%

Synthesis of Tamarind Gum and Poly (N‐isopropyl acrylamide)‐based Copolymer through Atom Transfer Radical Polymerization for Dual‐responsive Release Study

Karmakar,

Pal

2023

ChemistrySelect

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Over the past decades, thermoresponsive polymers are attracted much scientific attention and can be widely used in a wide range of applications. Synthesis of polymers throughCfunctionalization of polysaccharide using synthetic materials paves the way for producing much desirable natural biopolymer‐based copolymers. Therefore, this study reported about synthesis of thermo and pH‐responsive polymers, based on tamarind kernel polysaccharide (TKP) and poly (N‐isopropyl acrylamide) (pNIPAM) through atom transfer radical polymerization (ATRP) with controlled polymer chain length. The chemical structure and surface morphology have been investigated by different characterization techniques. Lower Critical Solution Temperature (LCST) confirmed the thermo‐responsive nature of the copolymer. The self‐aggregation among the polymer chains was found above LCST (34 °C). Rheological characterizations suggested that our prepared copolymers are non‐Newtonian shear thinning in nature. Finally, the developed material shows worthy efficacy towards the thermo‐responsive release of encapsulated dye at pH 7.4 (53 % and 65 % at 37 °C and 25 °C, respectively) suggesting that our prepared material could be a good candidate for therapeutic release in tissue engineering application.

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Advances in injectable hydrogel: Design, functional regulation, and biomedical applications

Karmakar,

Velu,

Vineeth Kumar

et al. 2023

Polymers for Advanced Techs

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Recently, injectable hydrogels have been considered smart materials and have been widely researched for their use as scaffolds. They resemble the extracellular matrix of native tissue and have the capability for homogeneous mixing with therapeutic agents. It can be implanted into living bodies with minimal invasiveness and usability for irregularly shaped sites. Such unique features make the injectable hydrogels as promising materials in tissue engineering, drug delivery system, and gene/protein delivery. This review article provides a comprehensive overview of the different mechanisms employed in the preparation of injectable hydrogel, as well as a detailed exploration of its applications in the biomedical field. Furthermore, the article highlights the critical importance of developing injectable hydrogels as market‐viable products, highlighting their potential impact in the field of regenerative medicine.

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Synthesis of an amphiphilic copolymer using biopolymer-dextran via a combination of ROP and RAFT techniques

Abstract: Ring-opening polymerization (ROP) and reversible addition–fragmentation chain-transfer (RAFT) polymerization are efficient synthetic approaches to develop self-assembled copolymers with narrow dispersity (Đ).

Cited by 6 publications

References 41 publications

Synthesis and Characterizations of Bioactive Glass Nanoparticle-Incorporated Triblock Copolymeric Injectable Hydrogel for Bone Tissue Engineering

Synthesis and Characterizations of Bioactive Glass Nanoparticle-Incorporated Triblock Copolymeric Injectable Hydrogel for Bone Tissue Engineering

Synthesis of Tamarind Gum and Poly (N‐isopropyl acrylamide)‐based Copolymer through Atom Transfer Radical Polymerization for Dual‐responsive Release Study

Advances in injectable hydrogel: Design, functional regulation, and biomedical applications

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