Synthesis of an amantadine-based novel Schiff base and its transition metal complexes as potential ALP, α-amylase, and α-glucosidase inhibitors

Abstract

Metal complex formation of a Schiff base ligand with Zn(ii), Co(ii), Cr(iii), and VO(iv). α-Amylase and α-glucosidase inhibition by these metal complexes.

Complexes of adamantane-derived Schiff bases

“…These derivatives have been discovered to disrupt various enzymes, showcasing diverse therapeutic activities such as anti-inflammatory [7], anti-viral [8], and anti-Parkinson [9]. They serve as antimicrobial-anticancer DHFR inhibitors [10][11][12], and they are also known as antidiabetic agents [13]. The incorporation of the adamantane moiety enhances CNS penetration, making it valuable for targeting CNS drugs [3].…”

“…Various metal complexes of amantadine-based ligands, including platinum(II) and platinum(IV) complexes known for their anticancer efficacy, have been synthesized and documented in the literature. Silver complexes with amantadine and memantine have been reported as potent antibacterial agents against both Grampositive and Gram-negative strains [13].…”