Synthesis of Ammonium Trichloromonoammineplatinate(II) Improved through Control of Temperature.

Analogues of Cis‐ and Transplatin with a Rich Solution Chemistry: cis‐[PtCl2(NH3)(1‐MeC‐N3)] and trans‐[PtI2(NH3)(1‐MeC‐N3)]

“…[44] Experimental Section Materials:C ytosine, AgNO 3 ,K 2 PtCl 4 ,K I, and KBr were of commercial origin and used as received. cis-[PtCl 2 (NH 3 ) 2 ], [47] 1-MeC, [48] cis-[PtCl(NH 3 ) 2 (1-MeC)]Cl, [9] trans-[PtI 2 (NH 3 )(1-MeC-N3)], [9] and NH 4 [PtCl 3 (NH 3 )] [49] were prepared according to literature procedures. 9-EtGH and 1-Et-5-MeC were of commercial origin (Chemogen, Konstanz).…”

Synthetic Methods for the Preparation of Platinum Anticancer Complexes

“…With careful control of temperature and reaction time, the ammonium salt of [Pt(NH 3 )Cl 3 ] − was reportedly isolated in 90% yield, also by the action of hydrochloric acid on cisplatin, but in the absence of a Pt metal catalyst. 127 …”

On the Heterogeneous Nature of Cisplatin‐1‐Methyluracil Complexes: Coexistence of Different Aggregation Modes and Partial Loss of NH3 Ligands as Likely Explanation

“…In Scheme 2 (right side) we have also taken into account the possibility that a NH 3 ligand is removed from 1 a as a consequence of the kinetic trans‐ effect of the chloride ligand to produce 1 c and its hydrolysis products, respectively. In general, and in particular for preparative purposes, a large excess of chloride (HCl, NEt 4 Cl) and forcing conditions (elevated temperature) are necessary to convert, for example, cis‐ [Pt(NH 3 ) 2 Cl 2 ] completely into [Pt(NH 3 )Cl 3 ] − , [22] but there are also cases of NH 3 release under mild conditions, [23] albeit in low yield. The latter situation, possibly also relevant to 1 a here, might be rationalized by an interaction of neutral 1 a with chloride ions originating from partial hydrolysis of the very same species 1 a (Scheme 4).…”