Synthesis of Amide Derivatives of Quinolone and Their Antimicrobial Studies.

Abstract

Synthesis of Amide Derivatives of Quinolone and Their Antimicrobial Studies. -A large variety of quinolinyl amides [cf. (IX), (XI); 70 examples] is synthesized. Several derivatives, e.g. (IXb)-(IXe), (XIa), exhibit significant antibacterial activity. -(PATEL, N. B.; PATEL, A. L.; CHAUHAN, H. I.; Indian J. Chem., Sect. B: Org.

Poly (γ) glutamic acid: a unique microbial biopolymer with diverse commercial applicability

“…The preparation of γ-PGA-based hydrogels, the bonding of carboxyl group to nanoparticles, and development of γ-PGA and gelatin-based ionic hydrogels are gaining popularity ( Garcia et al, 2014 ; Gao C. et al, 2016 ; Chen et al, 2023 ; Yu et al, 2023 ). γ-PGA-derived biocompatible antimicrobial hydrogels (TCS (Triclosan), CHX (Chlorhexidine), and PHMB (Polyhexamethylene biguanide)) have been prepared using electrospun nanofibers and bulk, which displayed promising antimicrobial efficacy against gram-positive staphylococcus aureus and gram-negative E. coli ( Patel et al, 2007 ; Vedadghavami et al, 2017 ; Kasbiyan et al, 2022 ). The antimicrobial activity of chitosan-γ-PGA polyelectrolyte complex hydrogels and γ-PGA-coated magnetite particles have been reported against S. aureus and E. coli ( Tsao et al, 2010 ; Inbaraj et al, 2011 ).…”

Synthesis and antimicrobial study of fluoroquinolone-based 4-thiazolidinones

“…We observed from the literature survey that the fluoroquinolones with hydrolyzable group, viz. amide and ester (Patel and Bhagat, 2006;Patel and Modi, 2006;Patel et al, 2007;Sharma and Jain, 2008), were synthesized and some of the compounds were found potent. Hence, we decided to synthesize thiazolidinones and Schiff bases incorporated fluoroquinolones through the hydrolyzable amide linkage to observe the variation in antimicrobial activity (Scheme 1).…”