Abstract:A simple synthetic approach to imidazolyl-substituted unsaturated amino acid esters 2 starting from the diaminomaleonitrile derivative 5 is reported. This synthesis involves the formation of the imidazole ring with triethyl orthoformate followed by an oxazolone ring-opening reaction with alcohols.
ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
New 1,3-o xa zol-5(4H)-one (3a-b) was synthesized by cyclizat ion of[(Pyridyl-3-yl-carbonyl)amino]acetic acid (2). The starting were readily obtained by acylation of 2-amino acetic acid (Glycine) with nicotinoyl chloride. Imidazo le was synthesized by reaction of compounds (3a-b) with hydrazine hydrate (99%). Co mpounds (4a-b) were converted into a variety of derivatives. All new co mpounds were characterized by 1 H NM R and FTIR spectroscopy.
scite is a Brooklyn-based organization that helps researchers better discover and understand research articles through Smart Citations–citations that display the context of the citation and describe whether the article provides supporting or contrasting evidence. scite is used by students and researchers from around the world and is funded in part by the National Science Foundation and the National Institute on Drug Abuse of the National Institutes of Health.