Synthesis of aliphatic polyesters by polycondensation using inorganic acid as catalyst

Sokolsky-Papkov, Marina; Langer, Robert; Domb, Abraham J.

doi:10.1002/pat.1541

Cited by 36 publications

(27 citation statements)

References 29 publications

(36 reference statements)

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“…Polycondensation of adipic acid or sebacic acid with aliphatic diols using an inorganic acid (H 3 PO 4 or H 2 SO 4 ) as catalyst combined with mild temperatures and low vacuum has also been evaluated [36]. This method was revealed effective to get aliphatic polyesters with appropriate molecular size (e.g., M W close to 85,000 g/mol for sebacic acid derivatives) for possible use in the preparation of degradable disposable medical supplies.…”

Section: Synthesis Of Poly(alkylene Dicarboxylate)smentioning

confidence: 99%

Synthesis, Properties and Applications of Biodegradable Polymers Derived from Diols and Dicarboxylic Acids: From Polyesters to Poly(ester amide)s

Díaz

Katsarava

Puiggalı́

2014

IJMS

208

112

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Poly(alkylene dicarboxylate)s constitute a family of biodegradable polymers with increasing interest for both commodity and speciality applications. Most of these polymers can be prepared from biobased diols and dicarboxylic acids such as 1,4-butanediol, succinic acid and carbohydrates. This review provides a current status report concerning synthesis, biodegradation and applications of a series of polymers that cover a wide range of properties, namely, materials from elastomeric to rigid characteristics that are suitable for applications such as hydrogels, soft tissue engineering, drug delivery systems and liquid crystals. Finally, the incorporation of aromatic units and α-amino acids is considered since stiffness of molecular chains and intermolecular interactions can be drastically changed. In fact, poly(ester amide)s derived from naturally occurring amino acids offer great possibilities as biodegradable materials for biomedical applications which are also extensively discussed.

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Section: Synthesis Of Poly(alkylene Dicarboxylate)smentioning

confidence: 99%

Synthesis, Properties and Applications of Biodegradable Polymers Derived from Diols and Dicarboxylic Acids: From Polyesters to Poly(ester amide)s

Díaz

Katsarava

Puiggalı́

2014

IJMS

208

112

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“…The basic skeleton of the aliphatic polyesters are similar but pendent groups vary. These pendent groups contribute to the changes in molecular weight, crystallinity and that affects degradation rate [54].…”

Section: Saturated Aliphatic Polyestersmentioning

confidence: 99%

A review on biodegradable materials for cardiovascular stent application

Hou

Pan

et al. 2016

Front. Mater. Sci.

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A stent is a medical device designed to serve as a temporary or permanent internal scaffold to maintain or increase the lumen of a body conduit. The researchers and engineers diverted to investigate biodegradable materials due to the limitation of metallic materials in stent application such as stent restenosis which requires prolonged anti platelet therapy, often result in smaller lumen after implantation and obstruct re-stenting treatments. Biomedical implants with temporary function for the vascular intervention are extensively studied in recent years. The rationale for biodegradable stent is to provide the support for the vessel in predicted period of time and then degrading into biocompatible constituent. The degradation of stent makes the re-stenting possible after several months and also ameliorates the vessel wall quality. The present article focuses on the biodegradable materials for the cardiovascular stent. The objective of this review is to describe the possible biodegradable materials for stent and their properties such as design criteria, degradation behavior, drawbacks and advantages with their recent clinical and preclinical trials.

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“…There is large amount of scientific data on the synthesis of castor oil/ricinoleic acid (RA)‐based copolymer materials. Some of them have potential application in biomedical field, such as drug delivery systems, implants, or tissue engineering materials . For example, copolymers of ricinoleic and lactic acid, with molecular weight of M w = 3000–13 000 gmol −1 , were synthesized by ring‐opening polymerization, melt condensation, or transesterification.…”

Section: Introductionmentioning

confidence: 99%

“…Some of them have potential application in biomedical field, such as drug delivery systems, implants, or tissue engineering materials. [19][20][21][22][23] For example, copolymers of ricinoleic and lactic acid, with molecular weight of M w = 3000-13 000 gmol −1 , were synthesized by ringopening polymerization, melt condensation, or transesterification. In drug release and degradation studies, these copolyesters showed almost zero-order weight loss kinetics and structuredependent release of hydrophobic drug.…”

Section: Introductionmentioning

confidence: 99%

Cost‐effective synthesis of polyricinoleate: Investigation of coating characteristics,in vitrodegradation, and antibacterial activity

Tonta

Sezer

Ölmez

et al. 2019

J of Applied Polymer Sci

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Ricinoleic acid (RA) is a component of various bio‐based copolymers. However, high‐molecular weight polyricinoleate homopolymers are not widely investigated due to high cost of commercial monomer and catalysts. In this work, we present low‐cost approach for the synthesis of high‐molecular‐weight polyricinoleate by preparing large amount of pure monomer and use of lipozyme TL IM as catalyst. First, polymerization conditions were optimized and comparative studies of medium‐molecular‐weight polyricinoleate (PRA‐M) of Mw = 30 000 gmol−1 and high‐molecular‐weight polyricinoleate (PRA‐H) of Mw = 72 000 gmol−1 were conducted. Polyricinoleates were characterized by common spectroscopic, chromatographic, and thermal methods. Solvent casting of polyricinoleates resulted in thin and continuous coating with perfectly smooth surface under SEM observation. AFM analysis of PRA films showed that surface roughness decreased with increasing molecular weight of polyricinoleate (roughness PRA‐M = 68.39 nm and PRA‐H = 57.36 nm). Degradation studies under in vitro conditions showed that both PRA‐M and PRA‐H showed good stability with only ~2% of mass loss after 6 months, possibly due to its hydrophobic nature and relatively high‐molecular weight. In contrast to RA, PRA‐M and PRA‐H do not have significant antibacterial effect on Staphylococcus aureus and Escherichia coli. © 2019 Wiley Periodicals, Inc. J. Appl. Polym. Sci. 2019, 136, 48172.

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Synthesis of aliphatic polyesters by polycondensation using inorganic acid as catalyst

Cited by 36 publications

References 29 publications

Synthesis, Properties and Applications of Biodegradable Polymers Derived from Diols and Dicarboxylic Acids: From Polyesters to Poly(ester amide)s

Synthesis, Properties and Applications of Biodegradable Polymers Derived from Diols and Dicarboxylic Acids: From Polyesters to Poly(ester amide)s

A review on biodegradable materials for cardiovascular stent application

Cost‐effective synthesis of polyricinoleate: Investigation of coating characteristics,in vitrodegradation, and antibacterial activity

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