Synthesis of Alginate-Curcumin Nanocomposite and Its Protective Role in TransgenicDrosophilaModel of Parkinson’s Disease

Abstract

The genetic models in Drosophila provide a platform to understand the mechanism associated with degenerative diseases. The model for Parkinson's disease (PD) based on normal human alpha-synuclein (αS) expression was used in the present study. The aggregation of αS in brain leads to the formation of Lewy bodies and selective loss of dopaminergic neurons due to oxidative stress. Polyphenols generally have the reduced oral bioavailability, increased metabolic turnover, and lower permeability through the blood brain barrier. In the present study, the effect of synthesized alginate-curcumin nanocomposite was studied on the climbing ability of the PD model flies, lipid peroxidation, and apoptosis in the brain of PD model flies. The alginate-curcumin nanocomposite at final doses of 10−5, 10−3, and 10−1 g/mL was supplemented with diet, and the flies were allowed to feed for 24 days. A significant dose-dependent delay in the loss of climbing ability and reduction in the oxidative stress and apoptosis in the brain of PD model flies were observed. The results suggest that alginate-curcumin nanocomposite is potent in delaying the climbing disability of PD model flies and also reduced the oxidative stress as well as apoptosis in the brain of PD model flies.

Effect of bromocriptine alginate nanocomposite (BANC) on a transgenic Drosophila model of Parkinson's disease

“…With the advent of new techniques and implementation of nanotechnology there has been a revolution for brain-specific drug delivery, imaging and diagnosis. For the treatment of CNS diseases, new nanostructured carriers of high drug-loading capacity and brain-targeting ability are needed to be explored ( Siddique et al, 2013 ; Yang, 2010 ).…”

Phenolic compounds prevent the oligomerization of α‐synuclein and reduce synaptic toxicity

“…In recent studies, Cur showed effectiveness on motor activity, lifespan, oxidative stress, and apoptosis in the transgenic Drosophila model of PD (Siddique et al . , ). In vivo experiments with animal models of α‐synucleinopathies should be conducted to elucidate the effectiveness of phenolic compounds on α‐synucleinopathies.…”

<p>Curcumin-loaded nanoparticles: a novel therapeutic strategy in treatment of central nervous system disorders</p>

“…In addition, it has been suggested that reduction of lipid peroxidation and apoptosis in the brain of animals could be due to the suppressive effect of ACNC on α-synuclein accumulation or result from the property of curcumin to scavengering free radicals. 54 Another study documented that curcuminloaded polysorbate 80-coated cerasome (CPC) nanoparticles hold the potential to moderate the release time of curcumin and produced a prolonged circulation time in the blood. Furthermore, CPC was combined with ultrasound-targeted microbubble destruction (UTMD) to locally open the BBB around the targeted brain nuclei.…”