Synthesis of Aldo-quinazolinones by Iodine-Induced Oxidative Condensation of Aldoses and o-Aminobenzamides

Abstract

A series of aldo-quinazolinones were synthesized by a one-pot iodine-induced oxidative condensation of the unprotected mono-/di-saccharides and o-aminobenzamides in the yields of 30%～80%, providing an effective protocol for the preparation of aldo-quinazolinones. The amount of iodine has an important effect on the reaction.