Synthesis of Ag/Cu and Cu/Zn bimetallic nanoparticles using toddy palm: Investigations of their antitumor, antioxidant and antibacterial activities

Merugu, Ramchander; Gothalwal, Ragini; Deshpande, Pallav Kaushik; Mandal, Surajit De; Padala, Gopikrishna; Chitturi, Kanchana Latha

doi:10.1016/j.matpr.2020.08.027

Cited by 45 publications

(17 citation statements)

References 25 publications

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“…When at least two metals are formed as NPs, combinatorial approaches, such as structural changes, deduction of the lattice parameters, and total electronic charge shift improvements, are expected [ 128 ]. Recently, bimetallic Ag/Cu and Cu/Zn [ 129 ], and trimetallic Cu/Cr/Ni [ 130 ] and CuO/NiO/ZnO [ 131 ] NPs have exhibited remarkably improved antimicrobial performance compared to monometallic NPs. Recent studies on the antimicrobial activities of metal and metal oxides, including mono-, bi-, and trimetallic NPs, against various bacterial strains and their respective mechanisms of action are shown in Table 3 .…”

Section: Antimicrobial Nanomaterialsmentioning

confidence: 99%

Combination Strategies of Different Antimicrobials: An Efficient and Alternative Tool for Pathogen Inactivation

Basavegowda

Baek

2022

Biomedicines

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Despite the discovery and development of an array of antimicrobial agents, multidrug resistance poses a major threat to public health and progressively increases mortality. Recently, several studies have focused on developing promising solutions to overcome these problems. This has led to the development of effective alternative methods of controlling antibiotic-resistant pathogens. The use of antimicrobial agents in combination can produce synergistic effects if each drug invades a different target or signaling pathway with a different mechanism of action. Therefore, drug combinations can achieve a higher probability and selectivity of therapeutic responses than single drugs. In this systematic review, we discuss the combined effects of different antimicrobial agents, such as plant extracts, essential oils, and nanomaterials. Furthermore, we review their synergistic interactions and antimicrobial activities with the mechanism of action, toxicity, and future directions of different antimicrobial agents in combination. Upon combination at an optimum synergistic ratio, two or more drugs can have a significantly enhanced therapeutic effect at lower concentrations. Hence, using drug combinations could be a new, simple, and effective alternative to solve the problem of antibiotic resistance and reduce susceptibility.

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Section: Antimicrobial Nanomaterialsmentioning

confidence: 99%

Combination Strategies of Different Antimicrobials: An Efficient and Alternative Tool for Pathogen Inactivation

Basavegowda

Baek

2022

Biomedicines

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“…The bimetallic Ag/Cu and Cu/Zn bimetallic nanoparticles were studied for antibacterial activity against Alcaligenes faecalis, Staphylococcus aureus, Citrobacter freundii, Klebsiella pneumoniae, and Clostridium perfringens. ( Merugu et al, 2021 ).…”

Section: Introductionmentioning

confidence: 99%

Green synthesis of MgO nanoparticles and its antibacterial properties

et al. 2023

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Magnesium oxide nanostructured particles (NP) were prepared using a simple solution combustion technique using different leaf extracts such as Mangifera indica (Mango - Ma), Azadirachta indica (Neem—Ne), and Carica papaya (Papaya—Pa) as surfactants. The highly crystalline phase of MgO nanostructures was confirmed by PXRD and FTIR studies for 2 h 500°C calcined samples. To analyze the characteristics of obtained material–MaNP, NeNP, and PaNP for dosimetry applications, thermoluminescence (TL) studies were carried out for Co-60 gamma rays irradiated samples in the dose range 10–50 KGy; PaNP and NeNP exhibited well-defined glow curve when compared with MaNP samples. In addition, it was observed that the TL intensity decreases, with increase in gamma dose and the glow peak temperature is shifted towards the higher temperature with the increase in heating rate. The glow peak was segregated using glow curve deconvolution and thermal cleaning method. Kinetic parameters estimated using Chen’s method, trap depth (E), and frequency factor (s) were found to be 0.699, 7.408, 0.4929, and 38.71, 11.008, and 10.71 for PaNP, NeNP, and MaNP respectively. The well-resolved glow curve, good linear behavior in the dose range of 10–50, KGy, and less fading were observed in PaNP as compared with MaNP and NeNP. Further, the antibacterial activity was checked against human pathogens such as Escherichia coli, Staphylococcus aureus, and Pseudomonas aeruginosa. A visible zone of clearance was observed at 200 and 100 μg/mL by the PaNP and NeNP, indicating the death of colonies by the nanoparticles. Therefore, PaNP nanomaterial is a potential phosphor material for dosimetry and antibacterial application compared to NeNP and MaNP.

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“…Добавление второго компонента приводило к повышению эффективности и снижению токсичности бикомпонентных НЧ, что было подтверждено на примере биметал-лических НЧ Ag-Au со структурой ядро-оболочка [9]. Исследования ряда авторов показали, что бикомпонентные НЧ Cu/Ag и Zn/Cu обладали эффективностью в отношении клеточной линии рака носоглотки (KB) [10] и клеток рака молочной железы (MDA-MB-231) [11].…”

Section: Introductionunclassified

Bicomponent Zno-Ag janus nanoparticles with high antitumor activity <I>in vitro</I>

2023

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Background. Nanoparticles (NPs) of zinc and silver oxide are promising antitumor agents, the use of which can enhance modern approaches to cancer treatment. Using bicomponent ZnO-Ag nanoparticles, one can increase the efficiency due to the occurrence of a synergistic antitumor effect. Among the main physicochemical properties that affect the antitumor activity of nanoparticles, one can distinguish their size and distribution of components inside the particle or their microstructure, however, these aspects are currently poorly understood.The aim of this study is the synthesis of ZnO-Ag nanoparticles using electrical explosive of wire technology and the in vitro study of the antitumor activity of NPs against breast ductal adenocarcinoma MCF-7 (ATCC HTB-22) and the HeLa cell line isolated from a cervical tumor.Material and Methods. ZnO-Ag nanoparticles were obtained by simultaneous electric explosion of zinc and silver twisted wires in a gas mixing atmosphere: argon and oxygen. The content of the components was regulated by varying the wire diameters. Physicochemical properties were studied using X-ray phase analysis, thermal desorption of nitrogen, and transmission electron microscopy. Antitumor activity in vitro was studied using the MTT test against HeLa and MCF-7 cell lines.Results. As a result of an electric explosion of twisted wires in an argon + oxygen gas mixture, ZnO-Ag NPs with different contents of components and the structure of Janus nanoparticles were obtained. The study of the physicochemical properties of nanoparticles showed that an increase in the silver content led to a decrease in the average particle size, an increase in their specific surface area, an increase in their photochemical activity and the ability to generate reactive oxygen species. The high antitumor activity of nanoparticles with a minimum silver content can be explained by a decrease in the size of silver fragments from 46 nm to 23 nm and a decrease in the average particle size from 92 nm to 54 nm. A decrease in the size of NPs and their components contributes to an increase in their solubility and, accordingly, cytotoxicity. In addition, a decrease in the size of crystallites makes it possible to increase the number and length of the ZnO-Ag interface.Conclusion. In the present study, bicomponent ZnO–Ag NPs were synthesized using the joint electric explosion of zinc and silver wires in a mixed atmosphere of argon and oxygen. A study of the physicochemical properties of nanoparticles was carried out and it was found that they all have the structure of Janus nanoparticles, an average size of 54 to 92 nm, and photochemical activity and the ability to generate ROS. Using the MTT test, the antitumor activity of NPs was confrmed using MCF-7 and HeLa cell lines. The high effciency of ZnO-Ag NPs containing 20% wt. silver indicates the possibility of using these NPs in antitumor therapy.

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Synthesis of Ag/Cu and Cu/Zn bimetallic nanoparticles using toddy palm: Investigations of their antitumor, antioxidant and antibacterial activities

Cited by 45 publications

References 25 publications

Combination Strategies of Different Antimicrobials: An Efficient and Alternative Tool for Pathogen Inactivation

Combination Strategies of Different Antimicrobials: An Efficient and Alternative Tool for Pathogen Inactivation

Green synthesis of MgO nanoparticles and its antibacterial properties

Bicomponent Zno-Ag janus nanoparticles with high antitumor activity <I>in vitro</I>

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